"Acute myeloid leukemia; Chronic lymphocytic leukemia; Leukemia; Lymphoma; Non-Hodgkins lymphoma; Refractory myeloid cancer; Small intestine cancer; Solid tumor, adult"^^ . "C0054173"^^ . "FDA"^^ . "Organic Chemical"^^ . . _:b630495 . "41959"^^ . _:b651787 . "41959"^^ . "Bryostatin 1"^^ . "Bryostatin IPTDCP01979" . "Pharmacologic Substance"^^ . _:b651788 . "B705008K112SYDTPNSC0339555" . _:b651786 . "Bryostatin 1SYDTPNSC0339555" . _:b651789 . _:b751286 . . _:b651787 . _:b651784 . _:b751281 _:b651784 . _:b651785 . _:b651784 . _:b651784 . _:b651785 . "C47H68O17"^^ . "A substance being studied in the treatment of cancer and certain brain conditions such as Alzheimer disease and stroke. It binds to an enzyme involved in cell growth and it may help anticancer drugs work better. Bryostatin 1 comes from a marine organism. It is a type of protein kinase C modulator.NCI-GLOSS" . _:b751283 _:b651786 . "C1026"^^ . _:b651785 . . _:b630495 _:b735772 . _:b751282 _:b651785 . "bryostatin 1PTNCI-GLOSSCDR0000045630" . _:b651786 . _:b751281 _:b751282 . _:b651788 . "Bryostatin-1"^^ . "Bryostatin 1PTNCI" . _:b630495 . _:b651787 . _:b735772 . _:b751284 _:b651787 . _:b751285 _:b651788 . _:b651789 . _:b651789 . "BRYOSTATIN 1PTFDA37O2X55Y9E" . . "Bryostatin 1"^^ . _:b751286 _:b651789 . _:b651788 . _:b751283 _:b751284 . _:b651786 . "B705008K112CNNCI" . _:b751282 _:b751283 . "83314-01-6"^^ . _:b751284 _:b751285 . "339555"^^ . _:b751285 _:b751286 . "37O2X55Y9E"^^ . _:b735772 _:b751281 . "A macrocyclic lactone isolated from the bryozoan Bugula neritina with antineoplastic activity. Bryostatin 1 binds to and inhibits the cell-signaling enzyme protein kinase C, resulting in the inhibition of tumor cell proliferation, the promotion of tumor cell differentiation, and the induction of tumor cell apoptosis. This agent may act synergistically with other chemotherapeutic agents. (NCI04)NCI" .