"AF802CNNCI" . . "ALK Inhibitor CH5424802PTNCI" . "An orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity. Upon administration, ALK inhibitor CH542480 binds to and inhibits ALK kinase, ALK fusion proteins as well as the gatekeeper mutation ALKL1196M known as one of the mechanisms of acquired resistance to small-molecule kinase inhibitors. The inhibition leads to disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a series of tumors.NCI" . "CHEBI:62268"^^ . "733572"^^ . "ALK Inhibitor CH5424802"^^ . . "CL435908"^^ . "Pharmacologic Substance"^^ . "CH5424802CNNCI" . "ALK Inhibitor CH5424802"^^ . "733572"^^ . "C101790"^^ .