_:b646665 . "43067"^^ . _:b646668 . _:b629722 . . "TrisenoxBRNCI" . "Arsenous OxideSYNCI" . "FDA"^^ . "Arsenic Trioxide"^^ . _:b646667 . "arsenic trioxidePTNCI-GLOSSCDR0000046018" . _:b646666 . _:b738556 . "As2O3"^^ . "Inorganic Chemical"^^ . "TrisenoxPTNCI-GLOSSCDR0000523452" . "Pharmacologic Substance"^^ . "C1005"^^ . _:b748723 _:b646666 . _:b646669 . _:b646666 . "706363"^^ . . "1327-53-3"^^ . _:b748722 _:b646665 . "S7V92P67HO"^^ . "43067"^^ . _:b646667 . "Arsenic (III) OxideSYNCI" . _:b748724 _:b646667 . _:b748725 _:b646668 . "Arsenic Trioxide"^^ . . _:b748726 _:b646669 . "Arsenic SesquioxideSYNCI" . _:b748726 . _:b646666 . . "Arsenous AcidSYNCI" . . _:b646667 . _:b646665 . . "Advanced neuroblastoma or other pediatric solid tumors; metastatic stage IVA or IVB hormone-refractory prostate cancer; myelodysplastic syndromes"^^ . "A small-molecule arsenic compound with antineoplastic activity. The mechanism of action of arsenic trioxide is not completely understood. This agent causes damage to or degradation of the promyelocytic leukemia protein/retinoic acid receptor-alpha (PML/RARa) fusion protein; induces apoptosis in acute promyelocytic leukemia (APL) cells and in many other tumor cell types; promotes cell differentiation and suppresses cell proliferation in many different tumor cell types; and is pro-angiogenic. (NCI04)NCI" . "CHEBI:30621"^^ . "Refractory leukemia or lymphoma; resistant chronic phase chronic myelogenous leukemia; acute promyelocytic leukemia; recurrent or refractory multiple myeloma; locally advanced or metastatic non-small cell lung cancer"^^ . "C0052416"^^ . _:b646668 . "Arsenous Acid AnhydrideSYNCI" . _:b646665 . "A drug used to treat acute promyelocytic leukemia (APL) that has not gotten better or that has come back after treatment with other anticancer drugs. It is also being studied in the treatment of other types of cancer.NCI-GLOSS" . "Arsenic_Trioxide"^^ . _:b748723 _:b748724 . _:b646669 . "Locally advanced or metastatic breast cancer; refractory testicular or extragonadal germ cell malignancies; refractory adenocarcinoma of the pancreas; advanced adenocarcinoma of the esophagus or gastroesophageal junction"^^ . _:b748722 _:b748723 . _:b738556 _:b748722 . _:b748724 _:b748725 . _:b629722 _:b738556 . "ARSENIC TRIOXIDEPTFDAS7V92P67HO" . _:b748725 _:b748726 . _:b646668 . "White ArsenicSYNCI" . "Myelodysplastic syndrome; multiple myeloma; chronic myeloid leukemia; acute myelocytic leukemia"^^ . _:b629722 . "Arsenic TrioxidePTNCI" . _:b646669 .