. . . "1"^^ . . . . . . . "26502"^^ . . . "27019"^^ . "Vinka alkaloidy\nA\u010Dkoli studie nebyly provedeny, flukonazol m\u016F\u017Ee zv\u00FD\u0161it plazmatick\u00E9 hladiny vinka alkaloid\u016F (nap\u0159. vinkristin a vinblastin) a v\u00E9st k neurotoxicit\u011B, pravd\u011Bpodobn\u011B zp\u016Fsoben\u00E9 inhibi\u010Dn\u00EDm vlivem na CYP3A4.\nVitamin A\nNa z\u00E1klad\u011B jednoho hl\u00E1\u0161en\u00E9ho p\u0159\u00EDpadu u jednoho pacienta u\u017E\u00EDvaj\u00EDc\u00EDho kombinovanou l\u00E9\u010Dbu all-trans retinovou kyselinou (kyselou formou vitaminu A) a flukonazolem, do\u0161lo k\u00A0rozvoji ne\u017E\u00E1douc\u00EDch \u00FA\u010Dink\u016F souvisej\u00EDc\u00EDch s CNS ve form\u011B pseudotumoru mozku, kter\u00E9 po ukon\u010Den\u00ED l\u00E9\u010Dby flukonazolem odezn\u011Bly."@cs .