. . . . . . "17939"^^ . "Fentanyl, l\u00E9\u010Div\u00E1 l\u00E1tka s vysokou clearance, je rychle a extenzivn\u011B metabolizov\u00E1n p\u0159ev\u00E1\u017En\u011B prost\u0159ednictv\u00EDm\nCYP3A4.\nSou\u010Dasn\u00E9 pod\u00E1v\u00E1n\u00ED s inhibitory cytochromu P450 3A4 (CYP3A4) (nap\u0159. ritonavir, ketokonazol, itrakonazol, flukonazol, vorikonazol, troleandomycin, klarithromycin, nelfinavir, nefazodon, verapamil, diltiazem a amiodaron) s transderm\u00E1ln\u00EDm fentanylem m\u016F\u017Ee zp\u016Fsobit vzestup plazmatick\u00FDch koncentrac\u00ED fentanylu, co\u017E by mohlo zv\u00FD\u0161it nebo prodlou\u017Eit l\u00E9\u010Debn\u00E9 i ne\u017E\u00E1douc\u00ED \u00FA\u010Dinky a m\u016F\u017Ee zp\u016Fsobit z\u00E1va\u017Enou respira\u010Dn\u00ED depresi."@cs . . . . "18465"^^ . . . . . . . "1"^^ . . . . .