. "Hypersenzitivita na metformin nebo na kteroukoli pomocnou l\u00E1tku.\nDiabetick\u00E1 ketoacid\u00F3za, diabetick\u00E9 prekoma.\nSelh\u00E1n\u00ED nebo dysfunkce ledvin (clearance kreatininu <\u00A060\u00A0ml/min).\nAkutn\u00ED stav s\u00A0mo\u017Enost\u00ED naru\u0161en\u00ED funkce ledvin, nap\u0159\u00EDklad dehydratace, t\u011B\u017Ek\u00E1 infekce, \u0161ok, nitro\u017Eiln\u00ED pod\u00E1n\u00ED kontrastn\u00EDch l\u00E1tek s\u00A0obsahem j\u00F3du (viz bod 4.4).\nAkutn\u00ED nebo chronick\u00E9 onemocn\u011Bn\u00ED, kter\u00E9 m\u016F\u017Ee zp\u016Fsobit tk\u00E1\u0148ovou hypoxii, nap\u0159\u00EDklad srde\u010Dn\u00ED nebo respira\u010Dn\u00ED selh\u00E1n\u00ED, ned\u00E1vn\u00FD infarkt myokardu, \u0161ok.\nNedostate\u010Dnost jater, akutn\u00ED intoxikace alkoholem, alkoholismus.\nKojen\u00ED.\n"@cs . . . . . . . . "4.3\tKontraindikace"@cs . "004.003" .