"004.008" . . . "Ne\u017E\u00E1douc\u00ED \u00FA\u010Dinky uveden\u00E9 n\u00ED\u017Ee byly hl\u00E1\u0161eny v\u00A0klinick\u00FDch studi\u00EDch s\u00A0tobolkami itrakonazolu a nebo jsou ze spont\u00E1nn\u00EDch hl\u00E1\u0161en\u00ED postmarketingov\u00E9ho sledov\u00E1n\u00ED v\u0161ech l\u00E9kov\u00FDch forem s\u00A0itrakonazolem. \nNej\u010Dast\u011Bji hl\u00E1\u0161en\u00E9 ne\u017E\u00E1douc\u00ED \u00FA\u010Dinky v\u00A0klinick\u00FDch studi\u00EDch, zahrnuj\u00EDc\u00EDch 2104 itrakonazolem l\u00E9\u010Den\u00FDch pacient\u016F s\u00A0dermatomyk\u00F3zami nebo onychomyk\u00F3zami, byly gastrointestin\u00E1ln\u00EDho, ko\u017En\u00EDho a jatern\u00EDho p\u016Fvodu. \nN\u00ED\u017Ee uveden\u00FD seznam uv\u00E1d\u00ED ne\u017E\u00E1douc\u00ED \u00FA\u010Dinky podle t\u0159\u00EDdy org\u00E1nov\u00FDch syst\u00E9m\u016F. V\u00A0r\u00E1mci ka\u017Ed\u00E9 t\u0159\u00EDdy jsou ne\u017E\u00E1douc\u00ED \u00FA\u010Dinky se\u0159azeny podle frekvence v\u00FDskytu za pou\u017Eit\u00ED n\u00E1sleduj\u00EDc\u00ED konvence: velmi \u010Dast\u00E9 (\u22651/10); \u010Dast\u00E9 (\u22651/100 a\u017E <1/10); m\u00E9n\u011B \u010Dast\u00E9 (\u22651/1000 a\u017E <1/100); vz\u00E1cn\u00E9 (\u22651/10000 a\u017E <1/1000); velmi vz\u00E1cn\u00E9 (<1/10000), nen\u00ED zn\u00E1mo (z dostupn\u00FDch \u00FAdaj\u016F nelze ur\u010Dit).\nPoruchy krve a lymfatick\u00E9ho syst\u00E9mu\nVz\u00E1cn\u00E9\t\t\tleukopenie, \nNen\u00ED zn\u00E1mo\t\tneutropenie, trombocytopenie\nPoruchy imunitn\u00EDho syst\u00E9mu\nM\u00E9n\u011B \u010Dast\u00E9\thypersenzitivita*,\nNen\u00ED zn\u00E1mo\tanafylaktick\u00E9 a anafylaktoidn\u00ED reakce, angioneurotick\u00FD ed\u00E9m, s\u00E9rov\u00E1 nemoc\nPoruchy metabolismu a v\u00FD\u017Eivy \nNen\u00ED zn\u00E1mo\t\thypertriglyceridemie, hypokalemie\nPoruchy nervov\u00E9ho syst\u00E9mu\nM\u00E9n\u011B \u010Dast\u00E9\t\tbolesti hlavy, z\u00E1vrat\u011B, parestezie,\nVz\u00E1cn\u00E9\t\t\thypestezie, \nNen\u00ED zn\u00E1mo\t\tperifern\u00ED neuropatie*\nPoruchy oka\nVz\u00E1cn\u00E9\t\t\tporuchy zraku,\nNen\u00ED zn\u00E1mo\t\trozmazan\u00E9 vid\u011Bn\u00ED a diplopie\nPoruchy ucha a labyrintu\nVz\u00E1cn\u00E9\t\t\ttinitus,\nNen\u00ED zn\u00E1mo\t\tdo\u010Dasn\u00E1 nebo trval\u00E1 ztr\u00E1ta sluchu*\nSrde\u010Dn\u00ED poruchy\nNen\u00ED zn\u00E1mo\t\tkongestivn\u00ED srde\u010Dn\u00ED selh\u00E1n\u00ED\nRespira\u010Dn\u00ED, hrudn\u00ED a mediastin\u00E1ln\u00ED poruchy\nNen\u00ED zn\u00E1mo\t\tplicn\u00ED ed\u00E9m\nGastrointestin\u00E1ln\u00ED poruchy\n\u010Cast\u00E9\t\t\tabdomin\u00E1ln\u00ED bolest, nauzea,\nM\u00E9n\u011B \u010Dast\u00E9\t\tzvracen\u00ED, pr\u016Fjem, z\u00E1cpa, dyspepsie, dysgeuzie, flatulence,\nVz\u00E1cn\u00E9\t\t\tpankreatitida\nPoruchy jater a \u017Elu\u010Dov\u00FDch cest\nM\u00E9n\u011B \u010Dast\u00E9\thyperbilirubinemie, zv\u00FD\u0161en\u00ED hladiny alaninaminotransfer\u00E1zy, zv\u00FD\u0161en\u00ED hladiny aspart\u00E1taminotransfer\u00E1zy, \nVz\u00E1cn\u00E9\t\t\tzv\u00FD\u0161en\u00ED hodnot jatern\u00EDch enzym\u016F,\nNen\u00ED zn\u00E1mo\takutn\u00ED jatern\u00ED selh\u00E1n\u00ED*, hepatitida, hepatotoxicita*\nPoruchy k\u016F\u017Ee a podko\u017En\u00ED tk\u00E1n\u011B\n\u010Cast\u00E9\tvyr\u00E1\u017Eka,\nM\u00E9n\u011B \u010Dast\u00E9\tkop\u0159ivka, alopecie, sv\u011Bd\u011Bn\u00ED,\nNen\u00ED zn\u00E1mo\ttoxick\u00E1 epiderm\u00E1ln\u00ED nekrol\u00FDza, Stevens-Johnson\u016Fv syndrom, erythema multiforme, exfoliativn\u00ED dermatitida, leukocytoklastick\u00E1 vaskulitida, fotosenzitivita\nPoruchy svalov\u00E9 a kostern\u00ED soustavy a pojivov\u00E9 tk\u00E1n\u011B\nNen\u00ED zn\u00E1mo\t\tmyalgie, artralgie\nPoruchy ledvin a mo\u010Dov\u00FDch cest\nVz\u00E1cn\u00E9\t\t\tpolakisurie, \nNen\u00ED zn\u00E1mo\t\tinkontinence mo\u010Di\nPoruchy reproduk\u010Dn\u00EDho syst\u00E9mu a prsu\nM\u00E9n\u011B \u010Dast\u00E9\t\tmenstrua\u010Dn\u00ED poruchy, \nNen\u00ED zn\u00E1mo\t\terektiln\u00ED dysfunkce\nCelkov\u00E9 poruchy a reakce v m\u00EDst\u011B aplikace\nM\u00E9n\u011B \u010Dast\u00E9\t\ted\u00E9m,\nVz\u00E1cn\u00E9\t\t\thore\u010Dka.\n* viz bod 4.4.\n"@cs . . "4.8\tNe\u017E\u00E1douc\u00ED \u00FA\u010Dinky"@cs . . .