"4.3\tKontraindikace"@cs . "004.003" . . . . . . "P\u0159\u00EDpravek Prokanazol je kontraindikov\u00E1n p\u0159i hypersenzitivit\u011B na l\u00E9\u010Divou l\u00E1tku nebo na kteroukoli pomocnou l\u00E1tku tohoto p\u0159\u00EDpravku uvedenou v\u00A0bod\u011B 6.1.\nJe kontraindikov\u00E1no u\u017E\u00EDv\u00E1n\u00ED n\u00E1sleduj\u00EDc\u00EDch l\u00E9k\u016F s\u00A0p\u0159\u00EDpravkem Prokanazol (viz bod 4.5):\nsubstr\u00E1ty metabolizovan\u00E9 CYP3A4, kter\u00E9 mohou prodlou\u017Eit QT interval, nap\u0159. terfenadin, astemizol, bepridil, mizolastin, cisaprid, dofetilid, levacetylmethadol (levomethadyl), chinidin, pimozid, sertindol \u2013 M\u016F\u017Ee doj\u00EDt ke zv\u00FD\u0161en\u00ED jejich plazmatick\u00FDch hladin, co\u017E m\u016F\u017Ee v\u00E9st k\u00A0prodlou\u017Een\u00ED QT intervalu a vz\u00E1cn\u00E9mu v\u00FDskytu torsade de pointes .\ninhibitory HMG-CoA redukt\u00E1zy metabolizovan\u00E9 CYP3A4, nap\u0159. atorvastatin, lovastatin a simvastatin,\ntriazolam a peror\u00E1ln\u00ED midazolam,\nn\u00E1melov\u00E9 alkaloidy, nap\u0159. dihydroergotamin, ergometrin (ergonovin), ergotamin a methylergometrin (methylergonovin),\neletriptan,\nnisoldipin.\nP\u0159\u00EDpravek Prokanazol nem\u00E1 b\u00FDt pod\u00E1v\u00E1n pacient\u016Fm s\u00A0prok\u00E1zanou ventrikul\u00E1rn\u00ED dysfunkc\u00ED, jako je kongestivn\u00ED srde\u010Dn\u00ED selh\u00E1n\u00ED (CHF) nebo CHF v\u00A0anamn\u00E9ze, s\u00A0v\u00FDjimkou l\u00E9\u010Dby \u017Eivot ohro\u017Euj\u00EDc\u00EDch nebo jin\u00FDch z\u00E1va\u017En\u00FDch infekc\u00ED (viz bod 4.4). \nTobolky Prokanazol nesm\u00ED b\u00FDt u\u017E\u00EDv\u00E1ny v\u00A0t\u011Bhotenstv\u00ED s v\u00FDjimkou\u00A0\u017Eivot ohro\u017Euj\u00EDc\u00EDch situac\u00ED (viz bod 4.6).\nPokud p\u0159\u00EDpravek u\u017E\u00EDvaj\u00ED \u017Eeny ve fertiln\u00EDm v\u011Bku, maj\u00ED pou\u017E\u00EDvat antikoncep\u010Dn\u00ED opat\u0159en\u00ED. Je nezbytn\u00E9 dodr\u017Eovat adekv\u00E1tn\u00ED antikoncep\u010Dn\u00ED opat\u0159en\u00ED a\u017E do p\u0159\u00ED\u0161t\u00ED menstruace po ukon\u010Den\u00ED terapie p\u0159\u00EDpravkem Prokanazol.\n"@cs .