. . . . "Ne\u017E\u00E1douc\u00ED \u00FA\u010Dinky obvykle rychle vymiz\u00ED bez nutnosti speci\u00E1ln\u00ED l\u00E9\u010Dby.\nKategorie \u010Detnost\u00ED jsou definov\u00E1ny dle n\u00E1sleduj\u00EDc\u00ED klasifikace_\nVelmi \u010Dast\u00E9 (\u22651/10) \n\u010Cast\u00E9 (\u22651/100 a\u017E <1/10) \nM\u00E9n\u011B \u010Dast\u00E9 (\u22651/1000 a\u017E <1/100) \nVz\u00E1cn\u00E9 (\u22651/10000 a\u017E <1/1000) \nVelmi vz\u00E1cn\u00E9 (<1/10000)\nNen\u00ED zn\u00E1mo (z dostupn\u00FDch \u00FAdaj\u016F nelze ur\u010Dit)\n\tPoruchy imunitn\u00EDho syst\u00E9mu\n\t\u010Cast\u00E9:\n\tAlergick\u00E9 reakce\n\tPsychiatrick\u00E9 poruchy\n\t\u010Cast\u00E9:\n\t\u00DAzkost*, insomnie, somnolence, emo\u010Dn\u00ED labilita\n\tM\u00E9n\u011B \u010Dast\u00E9:\nNen\u00ED zn\u00E1mo:\n\tStrach*\nDu\u0161evn\u00ED zm\u011Bny, euforie, neklid, neobvykl\u00FD pl\u00E1\u010D, agresivn\u00ED reakce, panick\u00E9 z\u00E1chvaty**\nP\u0159\u00EDznaky z\u00A0vysazen\u00ED: agitovanost*, \u00FAzkost*, emocion\u00E1ln\u00ED labilita, zmatenost, smyslov\u00E9 poruchy (viz bod 4.4)\n\tPoruchy nervov\u00E9ho syst\u00E9mu\n\t\u010Cast\u00E9:\n\tBolest hlavy, vertigo, agitovanost*, t\u0159es, sucho v \u00FAstech, hyperventilace, poruchy \u0159e\u010Di, parest\u00E9zie\n\tM\u00E9n\u011B \u010Dast\u00E9:\nNen\u00ED zn\u00E1mo:\n\tK\u0159e\u010De, z\u00E1chvaty (zejm\u00E9na u pacient\u016F s epilepsi\u00ED nebo z\u00E1va\u017Enou jatern\u00ED insuficienc\u00ED, hlavn\u011B po dlouhodob\u00E9 l\u00E9\u010Db\u011B benzodiazepiny nebo p\u0159i p\u0159ed\u00E1vkov\u00E1n\u00ED vice l\u00E9ky) \nSamovoln\u00E9 pohyby \n\tPoruchy oka\n\t\u010Cast\u00E9:\n\tDiplopie, strabismus, zv\u00FD\u0161en\u00E9 slzen\u00ED\n\tPoruchy ucha a labyrintu\n\tM\u00E9n\u011B \u010Dast\u00E9:\n\tPoruchy sluchu\n\tSrde\u010Dn\u00ED poruchy\n\t\u010Cast\u00E9:\n\tPalpitace*\n\tM\u00E9n\u011B \u010Dast\u00E9:\n\tTachykardie \u010Di bradykardie, extrasystola\n\tC\u00E9vn\u00ED poruchy\n\t\u010Cast\u00E9:\n\tZ\u010Derven\u00E1n\u00ED, hypotenze, ortostatick\u00E1 hypotenze; tranzitorn\u00ED hypertenze (p\u0159i probuzen\u00ED)\n\t\n\t\n\tRespira\u010Dn\u00ED, hrudn\u00ED a mediastin\u00E1ln\u00ED poruchy\n\tM\u00E9n\u011B \u010Dast\u00E9:\n\tDu\u0161nost, ka\u0161el, ucpan\u00FD nos, bolest na hrudi\n\tGastrointestin\u00E1ln\u00ED poruchy\n\tVelmi \u010Dast\u00E9:\n\tNauzea (b\u011Bhem anest\u00E9zie, zejm\u00E9na p\u0159i soub\u011B\u017En\u00E9m pou\u017Eit\u00ED s opi\u00E1ty)\n\t\u010Cast\u00E9:\n\tZvracen\u00ED (b\u011Bhem anest\u00E9zie, zejm\u00E9na p\u0159i soub\u011B\u017En\u00E9m pou\u017Eit\u00ED s\u00A0opi\u00E1ty), \u0161kytavka\n\tPoruchy k\u016F\u017Ee a podko\u017En\u00ED tk\u00E1n\u011B\n\t\u010Cast\u00E9:\n\tPocen\u00ED\n\tM\u00E9n\u011B \u010Dast\u00E9:\n\tBledost\n\tNen\u00ED zn\u00E1mo:\n\tZ\u010Derven\u00E1n\u00ED obli\u010Deje\n\tCelkov\u00E9 poruchy a reakce v\u00A0m\u00EDst\u011B aplikace\n\t\u010Cast\u00E9:\n\t\u00DAnava, bolest v\u00A0m\u00EDst\u011B vpichu\n\tM\u00E9n\u011B \u010Dast\u00E9:\n\tT\u0159es\n\tNen\u00ED zn\u00E1mo:\n\tZv\u00FD\u0161en\u00E9 vn\u00EDm\u00E1n\u00ED bolesti, zv\u00FD\u0161en\u00ED hmotnosti, zimnice\n*: po rychl\u00E9 injekci obecn\u011B nen\u00ED l\u00E9\u010Dba nutn\u00E1\nU pacient\u016F dlouhodob\u011B l\u00E9\u010Den\u00FDch benzodiazepiny m\u016F\u017Ee flumazenil v\u00E9st k abstinen\u010Dn\u00EDm p\u0159\u00EDznak\u016Fm. Mezi tyto p\u0159\u00EDznaky mohou pat\u0159it: nap\u011Bt\u00ED, neklid, \u00FAzkost, emocion\u00E1ln\u00ED labilita, zmatenost, smyslov\u00E9 poruchy, halucinace, t\u0159es a k\u0159e\u010De.\nRychl\u00E1 injekce vysok\u00FDch d\u00E1vek (v\u00EDce ne\u017E 1 mg) flumazenilu by nem\u011Bla b\u00FDt pod\u00E1v\u00E1na u pacient\u016F l\u00E9\u010Den\u00FDch vysok\u00FDmi d\u00E1vkami benzodiazepin\u016F a/nebo dlouhodob\u011B l\u00E9\u010Den\u00FDch (b\u011Bhem n\u011Bkolika t\u00FDdn\u016F p\u0159ed pod\u00E1n\u00EDm flumazenilu) benzodiazepiny. V\u00A0takov\u00E9m p\u0159\u00EDpad\u011B m\u016F\u017Ee rychl\u00E1 injekce vyvolat p\u0159\u00EDznaky z\u00A0vysazen\u00ED v\u010Detn\u011B neklidu, \u00FAzkosti, emo\u010Dn\u00ED lability a m\u00EDrn\u00E9 zmatenosti a smyslov\u00FDch poruch (viz bod 4.4.).\n**U pacient\u016F s\u00A0anamn\u00E9zou panick\u00E9 poruchy m\u016F\u017Ee flumazenil vyvolat z\u00E1chvaty paniky.\nD\u011Bti\nProfil ne\u017E\u00E1douc\u00EDch \u00FA\u010Dink\u016F u d\u011Bt\u00ED se obecn\u011B neli\u0161il v\u00FDrazn\u011B od profilu u dosp\u011Bl\u00FDch. P\u0159i pou\u017Eit\u00ED flumazenilu ke zru\u0161en\u00ED sedace u d\u011Bt\u00ED se m\u016F\u017Ee nav\u00EDc vyskytnout abnorm\u00E1ln\u00ED pl\u00E1\u010D, neklid a agresivn\u00ED reakce.\n"@cs . "Ne\u017E\u00E1douc\u00ED \u00FA\u010Dinky"@cs . . . . "004.008" .