. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "4.8. \tNe\u017E\u00E1douc\u00ED \u00FA\u010Dinky"@cs . . . . . . "004.008" . "Nej\u010Dast\u011Bji hl\u00E1\u0161en\u00FDmi ne\u017E\u00E1douc\u00EDmi \u00FA\u010Dinky (v\u00FDskyt \u2265 10 %) jsou: parkinsonismus, bolest hlavy a\nnespavost.\nD\u00E1le jsou uvedeny ne\u017E\u00E1douc\u00ED \u00FA\u010Dinky hl\u00E1\u0161en\u00E9 z klinick\u00FDch hodnocen\u00ED a post-marketingu. Pou\u017E\u00EDv\u00E1na je n\u00E1sleduj\u00EDc\u00ED terminologie a frekvence: velmi \u010Dast\u00E9 (\u22651/10), \u010Dast\u00E9 (\u22651/100 a\u017E <1/10), m\u00E9n\u011B \u010Dast\u00E9 (\u22651/1 000 a\u017E <1/100), vz\u00E1cn\u00E9 (\u22651/10 000 a\u017E < 1/1 000), velmi vz\u00E1cn\u00E9 (<1/10 000), nen\u00ED zn\u00E1mo (z dostupn\u00FDch \u00FAdaj\u016F nelze ur\u010Dit).\nV ka\u017Ed\u00E9 skupin\u011B \u010Detnost\u00ED jsou ne\u017E\u00E1douc\u00ED \u00FA\u010Dinky se\u0159azeny podle klesaj\u00EDc\u00ED z\u00E1va\u017Enosti.\nNe\u017E\u00E1douc\u00ED \u00FA\u010Dinky podle t\u0159\u00EDd org\u00E1nov\u00FDch syst\u00E9m\u016F a frekvence\nVy\u0161et\u0159en\u00ED\n\u010Cast\u00E9 \t\tZv\u00FD\u0161en\u00ED prolaktinu v krvia, zv\u00FD\u0161en\u00ED t\u011Blesn\u00E9 hmotnosti\nM\u00E9n\u011B \u010Dast\u00E9\tProdlou\u017Een\u00ED QT na EKG, abnorm\u00E1ln\u00ED EKG, zv\u00FD\u0161en\u00ED gluk\u00F3zy v krvi, zv\u00FD\u0161en\u00ED \t\ttransamin\u00E1z, sn\u00ED\u017Een\u00ED po\u010Dtu b\u00EDl\u00FDch krvinek, zv\u00FD\u0161en\u00ED t\u011Blesn\u00E9 teploty, zv\u00FD\u0161en\u00ED \t\tpo\u010Dtu eosinofil\u016F, sn\u00ED\u017Een\u00ED hemoglobinu, zv\u00FD\u0161en\u00ED kreatinfosfokin\u00E1zy v krvi\nVz\u00E1cn\u00E9 \t\tSn\u00ED\u017Een\u00ED t\u011Blesn\u00E9 teploty\nSrde\u010Dn\u00ED poruchy\n\u010Cast\u00E9 \t\tTachykardie\nM\u00E9n\u011B \u010Dast\u00E9 \tAtrioventrikul\u00E1rn\u00ED blok\u00E1da, ram\u00E9nkov\u00FD blok, atri\u00E1ln\u00ED fibrilace, sinov\u00E1 bradykardie, palpitace\nPoruchy krve a lymfatick\u00E9ho syst\u00E9mu\nM\u00E9n\u011B \u010Dast\u00E9 \tAn\u00E9mie, trombocytopenie\nVz\u00E1cn\u00E9 \t\tGranulocytopenie\nNen\u00ED zn\u00E1mo \tAgranulocyt\u00F3za\nPoruchy nervov\u00E9ho syst\u00E9mu\nVelmi \u010Dast\u00E9 \tParkinsonismusb, bolest hlavy\n\u010Cast\u00E9 \t\tAkatizieb, z\u00E1vra\u0165, t\u0159esb, dystonieb, somnolence, sedace, letargie, dyskinezeb\nM\u00E9n\u011B \u010Dast\u00E9 \tNereagov\u00E1n\u00ED na podn\u011Bty, ztr\u00E1ta v\u011Bdom\u00ED, synkopa, sn\u00ED\u017Een\u00E1 \u00FArove\u0148 vn\u00EDm\u00E1n\u00ED, \t\tcerebrovaskul\u00E1rn\u00ED p\u0159\u00EDhoda, transientn\u00ED ischemick\u00E1 p\u0159\u00EDhoda, dysartrie, porucha \t\tpozornosti, hypersomnie, postur\u00E1ln\u00ED z\u00E1vra\u0165, porucha rovnov\u00E1hy, tardivn\u00ED \t\tdyskineze, porucha \u0159e\u010Di, abnorm\u00E1ln\u00ED koordinace, hypestezie\nVz\u00E1cn\u00E9 \t\tNeuroleptick\u00FD malign\u00ED syndrom, diabetick\u00E9 koma, cerebrovaskul\u00E1rn\u00ED porucha, \t\tcerebr\u00E1ln\u00ED ischemie, porucha hybnosti\nPoruchy oka\n\u010Cast\u00E9 \t\tRozmazan\u00E9 vid\u011Bn\u00ED\nM\u00E9n\u011B \u010Dast\u00E9 \tKonjunktivitida, o\u010Dn\u00ED hyperemie, v\u00FDtok z oka, otok oka, such\u00E9 oko, zv\u00FD\u0161en\u00E1 \t\ttvorba slz, fotofobie\nVz\u00E1cn\u00E9 \t\tSn\u00ED\u017Een\u00ED ostrosti vid\u011Bn\u00ED, nekontrolovan\u00E9 pohyby o\u010D\u00ED, glaukom\nPoruchy ucha a labyrintu\nM\u00E9n\u011B \u010Dast\u00E9 \tBolest ucha, tinitus\nRespira\u010Dn\u00ED, hrudn\u00ED a mediastin\u00E1ln\u00ED poruchy\n\u010Cast\u00E9 \t\tDyspnoe, epistaxe, ka\u0161el, kongesce nosn\u00ED sliznice, faryngolarynge\u00E1ln\u00ED bolest\nM\u00E9n\u011B \u010Dast\u00E9 \tChr\u00E1p\u00E1n\u00ED, aspira\u010Dn\u00ED pneumonie, plicn\u00ED kongesce, poruchy d\u00FDch\u00E1n\u00ED, \u0161elest, \t\tkongesce d\u00FDchac\u00EDho traktu, dysfonie\nVz\u00E1cn\u00E9 \t\tSyndrom sp\u00E1nkov\u00E9 apnoe, hyperventilace\nGastrointestin\u00E1ln\u00ED poruchy\n\u010Cast\u00E9 \t\tZvracen\u00ED, pr\u016Fjem, z\u00E1cpa, nauzea, bolest b\u0159icha, dyspepsie, sucho v \u00FAstech, \t\t\u017Ealude\u010Dn\u00ED nevolnost\nM\u00E9n\u011B \u010Dast\u00E9 \tDysfagie, gastritida, inkontinence stolice, fekaloma\nVz\u00E1cn\u00E9 \t\tObstrukce st\u0159eva, pankreatitida, otok rt\u016F, cheilitida\nPoruchy ledvin a mo\u010Dov\u00FDch cest\n\u010Cast\u00E9 \t\tEnur\u00E9za\nM\u00E9n\u011B \u010Dast\u00E9 \tDysurie, inkontinence mo\u010Di, pollakisurie\nPoruchy k\u016F\u017Ee a podko\u017En\u00ED tk\u00E1n\u011B\n\u010Cast\u00E9 \t\tVyr\u00E1\u017Eka, eryt\u00E9m\nM\u00E9n\u011B \u010Dast\u00E9 \tAngioed\u00E9m, ko\u017En\u00ED l\u00E9ze, poruchy k\u016F\u017Ee, sv\u011Bd\u011Bn\u00ED, akn\u00E9, zm\u011Bna zbarven\u00ED poko\u017Eky, \t\talopecie, seboroick\u00E1 dermatitida, such\u00E1 k\u016F\u017Ee, hyperkerat\u00F3za\nVz\u00E1cn\u00E9 \t\tLupy\nPoruchy svalov\u00E9 a kostern\u00ED soustavy a pojivov\u00E9 tk\u00E1n\u011B\n\u010Cast\u00E9\t\tArtralgie, bolest zad, bolest kon\u010Detin\nM\u00E9n\u011B \u010Dast\u00E9 \tSvalov\u00E1 slabost, myalgie, bolest kr\u010Dn\u00ED p\u00E1te\u0159e, otoky kloub\u016F, abnorm\u00E1ln\u00ED \tdr\u017Een\u00ED \t\tt\u011Bla, ztuhlost kloub\u016F, muskuloskelet\u00E1ln\u00ED bolest na hrudi\nVz\u00E1cn\u00E9 \t\tRhabdomyol\u00FDza\nEndokrinn\u00ED poruchy\nVz\u00E1cn\u00E9 \t\tNepat\u0159i\u010Dn\u00E1 sekrece antidiuretick\u00E9ho hormonu\nPoruchy metabolismu a v\u00FD\u017Eivy\n\u010Cast\u00E9 \t\tZv\u00FD\u0161en\u00ED chuti k j\u00EDdlu, sn\u00ED\u017Een\u00ED chuti k j\u00EDdlu\nM\u00E9n\u011B \u010Dast\u00E9 \tAnorexie, polydipsie\nVelmi vz\u00E1cn\u00E9 \tDiabetick\u00E1 ketoacid\u00F3za\nNen\u00ED zn\u00E1mo \tHyperhydratace\nInfekce a infestace \n\u010Cast\u00E9 \t\tPneumonie, ch\u0159ipka, bronchitida, infekce horn\u00EDch cest d\u00FDchac\u00EDch, infekce \t\tmo\u010Dov\u00E9ho \u00FAstroj\u00ED\nM\u00E9n\u011B \u010Dast\u00E9 \tSinusitida, virov\u00E1 infekce, infekce ucha, tonsilitida, celulitida, z\u00E1n\u011Bt st\u0159edn\u00EDho \t\tucha, infekce oka, lokalizovan\u00E1 infekce, akarodermatitida, infekce d\u00FDchac\u00EDch \t\tcest, z\u00E1n\u011Bt mo\u010Dov\u00E9ho m\u011Bch\u00FD\u0159e, onychomyk\u00F3za\nVz\u00E1cn\u00E9 \t\tChronick\u00FD z\u00E1n\u011Bt st\u0159edn\u00EDho ucha\nC\u00E9vn\u00ED poruchy\nM\u00E9n\u011B \u010Dast\u00E9 \tHypotenze, ortostatick\u00E1 hypotenze, n\u00E1valy\nNen\u00ED zn\u00E1mo\t\u017Diln\u00ED tromboembolismus (v\u010Detn\u011B plicn\u00ED embolie a hlubok\u00E9 \u017Eiln\u00ED tromb\u00F3zy)\nCelkov\u00E9 poruchy a reakce v m\u00EDst\u011B aplikace\n\u010Cast\u00E9 \t\tPyrexie, \u00FAnava, perifern\u00ED otok, astenie, bolest na hrudi\nM\u00E9n\u011B \u010Dast\u00E9 \tOtok obli\u010Deje, poruchy ch\u016Fze, abnorm\u00E1ln\u00ED pocity, liknavost, p\u0159\u00EDznaky podobn\u00E9 \t\tch\u0159ipce, \u017E\u00EDze\u0148, t\u00ED\u017Ee na hrudi, zimnice\nVz\u00E1cn\u00E9 \t\tGeneralizovan\u00FD otok, hypotermie, abstinen\u010Dn\u00ED p\u0159\u00EDznaky, studen\u00E9 konce kon\u010Detin\nPoruchy imunitn\u00EDho syst\u00E9mu\nM\u00E9n\u011B \u010Dast\u00E9 \tP\u0159ecitliv\u011Blost\nVz\u00E1cn\u00E9 \t\tL\u00E9kov\u00E1 p\u0159ecitliv\u011Blost\nNen\u00ED zn\u00E1mo \tAnafylaktick\u00E1 reakce\nPoruchy jater a \u017Elu\u010Dov\u00FDch cest\nVz\u00E1cn\u00E9\t\t \u017Dloutenka\nPoruchy reproduk\u010Dn\u00EDho syst\u00E9mu a prsu\nM\u00E9n\u011B \u010Dast\u00E9 \tAmenorea, sexu\u00E1ln\u00ED dysfunkce, erektiln\u00ED dysfunkce, porucha ejakulace, \t\t\tgalaktorea, gynekomastie, poruchy menstruace, vagin\u00E1ln\u00ED v\u00FDtok\nNen\u00ED zn\u00E1mo \tPriapismus\nStavy spojen\u00E9 s t\u011Bhotenstv\u00EDm, \u0161estined\u011Bl\u00EDm a perinat\u00E1ln\u00EDm obdob\u00EDm \nNen\u00ED zn\u00E1mo Syndrom z vysazen\u00ED l\u00E9ku u novorozenc\u016F (viz bod 4.6.) \nPsychiatrick\u00E9 poruchy\nVelmi \u010Dast\u00E9 \tNespavost\n\u010Cast\u00E9 \t\t\u00DAzkost, agitovanost, porucha sp\u00E1nku\nM\u00E9n\u011B \u010Dast\u00E9 \tZmatenost, m\u00E1nie, sn\u00ED\u017Een\u00ED libida, nete\u010Dnost, nervozita\nVz\u00E1cn\u00E9 \t\tAnorgasmie, otup\u011Blost\na Hyperprolaktinemie m\u016F\u017Ee v n\u011Bkter\u00FDch p\u0159\u00EDpadech v\u00E9st ke gynekomastii, poruch\u00E1m menstruace,\namenoree a galaktoree.\nb Mohou se objevit extrapyramidov\u00E9 p\u0159\u00EDznaky: Parkinsonismus (hypersekrece slin, muskuloskelet\u00E1ln\u00ED ztuhlost, parkinsonismus, slin\u011Bn\u00ED, rigidn\u00ED skus, bradykineze, hypokineze,\nztuhlost obli\u010Dejov\u00FDch sval\u016F, svalov\u00E9 nap\u011Bt\u00ED, akineze, ztuhlost \u0161\u00EDje, svalov\u00E1 ztuhlost, parkinsonovsk\u00E1 ch\u016Fze a abnorm\u00E1ln\u00ED glabel\u00E1rn\u00ED reflex), akatisie (akatisie, neklid, hyperkineze a\nsyndrom neklidn\u00FDch nohou), t\u0159es, dyskineze (dyskineze, svalov\u00E9 z\u00E1\u0161kuby, choreoatet\u00F3za, atet\u00F3za a myoklonus), dystonie.\nDystonie zahrnuje dystonii, svalov\u00E9 spasmy, hypertonii, tortikolis, mimovoln\u00ED svalov\u00E9 kontrakce, svalov\u00E9 kontrakce, blefarospasmus, okulogyraci, paral\u00FDzu jazyka, faci\u00E1ln\u00ED spasmus,\nlaryngospasmus, myotonii, opistotonus, orofaringe\u00E1ln\u00ED spasmus, pleurototonus, spasmus jazyka\na trismus. Tremor zahrnuje tremor a klidov\u00FD tremor p\u0159i parkinsonismu. Je nutno poznamenat, \u017Ee\nje zahrnuto \u0161ir\u0161\u00ED spektrum p\u0159\u00EDznak\u016F, kter\u00E9 nemusej\u00ED b\u00FDt nutn\u011B extrapyramidov\u00E9ho p\u016Fvodu.\nN\u00E1sleduj\u00EDc\u00ED seznam ne\u017E\u00E1douc\u00EDch reakc\u00ED spojovan\u00FDch s\u00A0pod\u00E1v\u00E1n\u00EDm risperidonu jsou ne\u017E\u00E1douc\u00ED reakce, pozorovan\u00E9 b\u011Bhem klinick\u00FDch studi\u00ED, ve kter\u00FDch bylo sledov\u00E1no pod\u00E1v\u00E1n\u00ED injek\u010Dn\u00EDho risperidonu s\u00A0prodlou\u017Een\u00FDm uvol\u0148ov\u00E1n\u00EDm. Tyto ne\u017E\u00E1douc\u00ED reakce v\u0161ak nebyly pozorov\u00E1ny v\u00A0klinick\u00FDch studi\u00EDch, ve kter\u00FDch byl risperidon pod\u00E1v\u00E1n peror\u00E1ln\u011B. Tento seznam nezahrnuje ne\u017E\u00E1douc\u00ED reakce jednozna\u010Dn\u011B spojovan\u00E9 s\u00A0pod\u00E1v\u00E1n\u00EDm injek\u010Dn\u00EDho risperidonu s\u00A0prodlou\u017Een\u00FDm uvol\u0148ov\u00E1n\u00EDm. \nDal\u0161\u00ED ne\u017E\u00E1douc\u00ED reakce hl\u00E1\u0161en\u00E9 v\u00A0souvislosti s\u00A0pod\u00E1v\u00E1n\u00EDm injek\u010Dn\u00EDho risperidonu s\u00A0prodlou\u017Een\u00FDm uvol\u0148ov\u00E1n\u00EDm, kter\u00E9 v\u0161ak nebyly hl\u00E1\u0161eny v\u00A0souvislosti s\u00A0risperidonem pod\u00E1van\u00FDm peror\u00E1ln\u011B, se\u0159azen\u00E9 podle t\u0159\u00EDd org\u00E1nov\u00FDch syst\u00E9m\u016F:\nVy\u0161et\u0159en\u00ED \nSn\u00ED\u017Een\u00ED t\u011Blesn\u00E9 hmotnosti, zv\u00FD\u0161en\u00ED gama-glutamyltransfer\u00E1zy, zv\u00FD\u0161en\u00ED jatern\u00EDch enzym\u016F\nSrde\u010Dn\u00ED poruchy\nBradykardie\nPoruchy krve a lymfatick\u00E9ho syst\u00E9mu\nNeutropenie\nPoruchy nervov\u00E9ho syst\u00E9mu\nParestezie, k\u0159e\u010De\nPoruchy oka\nBlefarospasmus\nPoruchy ucha a labyrintu\nVertigo\nGastrointestin\u00E1ln\u00ED poruchy\nBolesti zub\u016F, k\u0159e\u010D jazyka\nPoruchy k\u016F\u017Ee a podko\u017En\u00ED tk\u00E1n\u011B\nEkz\u00E9m\nPoruchy svalov\u00E9 a kostern\u00ED soustavy a pojivov\u00E9 tk\u00E1n\u011B\nBolest h\u00FD\u017E\u010Fov\u00FDch sval\u016F\nInfekce a infestace\nInfekce d\u00FDchac\u00EDho \u00FAstroj\u00ED, infekce, gastroenteritida, podko\u017En\u00ED abscesy\nPoran\u011Bn\u00ED, otravy a procedur\u00E1ln\u00ED komplikace\nP\u00E1dy\nC\u00E9vn\u00ED poruchy\nHypertenze\nCelkov\u00E9 poruchy a reakce v m\u00EDst\u011B aplikace\nBolest\nPsychiatrick\u00E9 poruchy\nDeprese\n\u00DA\u010Dinky t\u0159\u00EDdy\nPodobn\u011B jako u jin\u00FDch antipsychotik byly po uveden\u00ED na trh hl\u00E1\u0161eny velmi vz\u00E1cn\u00E9 p\u0159\u00EDpady\nprodlou\u017Een\u00ED QT intervalu. Dal\u0161\u00ED \u00FA\u010Dinky na srdce spojen\u00E9 s touto skupinou p\u0159\u00EDpravk\u016F hl\u00E1\u0161en\u00E9 u antipsychotik, kter\u00E9 prodlu\u017Euj\u00ED QT interval, zahrnuj\u00ED ventrikul\u00E1rn\u00ED arytmii, ventrikul\u00E1rn\u00ED fibrilaci, ventrikul\u00E1rn\u00ED tachykardii, n\u00E1hl\u00E9 \u00FAmrt\u00ED, z\u00E1stavu srdce a torsade de pointes.\nP\u0159\u00EDr\u016Fstek na t\u011Blesn\u00E9 hmotnosti\nPod\u00EDl pacient\u016F se schizofreni\u00ED l\u00E9\u010Den\u00FDch risperidonem a placebem, kte\u0159\u00ED dos\u00E1hli p\u0159\u00EDr\u016Fstku\nna t\u011Blesn\u00E9 hmotnosti \u2265 7 %, byl porovn\u00E1n v souhrnn\u00E9 anal\u00FDze 6 - 8t\u00FDdenn\u00EDch placebem\nkontrolovan\u00FDch klinick\u00FDch hodnocen\u00ED; z\u00E1v\u011Brem byl statisticky v\u00FDznamn\u011B v\u011Bt\u0161\u00ED p\u0159\u00EDr\u016Fstek na t\u011Blesn\u00E9 hmotnosti u pacient\u016F l\u00E9\u010Den\u00FDch risperidonem (18 %) oproti placebu (9 %). V souhrnn\u00E9\nanal\u00FDze 3t\u00FDdenn\u00EDch studi\u00ED u dosp\u011Bl\u00FDch pacient\u016F s akutn\u00ED m\u00E1ni\u00ED byl v\u00FDskyt p\u0159\u00EDr\u016Fstku na t\u011Blesn\u00E9\nhmotnosti \u2265 7 % v z\u00E1v\u011Bru studie srovnateln\u00FD u skupiny s risperidonem (2,5 %) a u skupiny s placebem (2,4 %) a byl m\u00EDrn\u011B vy\u0161\u0161\u00ED u skupiny s aktivn\u00ED kontrolou (3,5 %).\nV populaci d\u011Bt\u00ED a mladistv\u00FDch s poruchami chov\u00E1n\u00ED a jin\u00FDmi disruptivn\u00EDmi poruchami chov\u00E1n\u00ED byl v dlouhodob\u00FDch klinick\u00FDch studi\u00EDch st\u0159edn\u00ED n\u00E1r\u016Fst t\u011Blesn\u00E9 hmotnosti 7,3 kg po 12 m\u011Bs\u00EDc\u00EDch l\u00E9\u010Dby. O\u010Dek\u00E1van\u00FD p\u0159\u00EDr\u016Fstek na t\u011Blesn\u00E9 hmotnosti norm\u00E1ln\u00EDch d\u011Bt\u00ED mezi 5 - 12 lety je 3 a\u017E 5 kg za rok. Mezi 12 - 16 rokem v\u011Bku je p\u0159\u00EDr\u016Fstek na t\u011Blesn\u00E9 hmotnosti 3 a\u017E 5 kg za rok zachov\u00E1n u d\u00EDvek, zat\u00EDmco u chlapc\u016F je p\u0159\u00EDr\u016Fstek p\u0159ibli\u017En\u011B 5 kg za rok.\nDal\u0161\u00ED informace u zvl\u00E1\u0161tn\u00EDch populac\u00ED\nNe\u017E\u00E1douc\u00ED \u00FA\u010Dinky, kter\u00E9 byly hl\u00E1\u0161eny s vy\u0161\u0161\u00EDm v\u00FDskytem u star\u0161\u00EDch pacient\u016F s demenc\u00ED nebo\npediatrick\u00FDch pacient\u016F ne\u017E u dosp\u011Bl\u00E9 populace, jsou uvedeny n\u00ED\u017Ee:\nStar\u0161\u00ED pacienti s demenc\u00ED\nFrekvence transientn\u00EDch ischemick\u00FDch p\u0159\u00EDhod a cerebrovaskul\u00E1rn\u00EDch p\u0159\u00EDhod hl\u00E1\u0161en\u00FDch jako ne\u017E\u00E1douc\u00ED \u00FA\u010Dinky v klinick\u00FDch hodnocen\u00EDch u star\u0161\u00EDch pacient\u016F byly 1,4 %, resp. 1,5 %. D\u00E1le byly s\u00A0frekvenc\u00ED \u2265 5 % a s nejm\u00E9n\u011B dvojn\u00E1sobnou frekvenc\u00ED ne\u017E u dosp\u011Bl\u00E9 populace hl\u00E1\u0161eny u star\u0161\u00EDch pacient\u016F s demenc\u00ED tyto ne\u017E\u00E1douc\u00ED \u00FA\u010Dinky: infekce mo\u010Dov\u00FDch cest, perifern\u00ED otok, letargie a ka\u0161el.\nPediatri\u010Dt\u00ED pacienti\nU pediatrick\u00FDch pacient\u016F (5 a\u017E 17 let) byly s frekvenc\u00ED \u2265 5 % a s nejm\u00E9n\u011B dvojn\u00E1sobnou frekvenc\u00ED ne\u017E v klinick\u00FDch studi\u00EDch u dosp\u011Bl\u00E9 populace hl\u00E1\u0161eny tyto ne\u017E\u00E1douc\u00ED \u00FA\u010Dinky: somnolence/sedace, \u00FAnava, bolest hlavy, zv\u00FD\u0161en\u00ED chuti k j\u00EDdlu, zvracen\u00ED, infekce horn\u00EDch cest d\u00FDchac\u00EDch, kongesce nosn\u00ED sliznice, bolest b\u0159icha, z\u00E1vra\u0165, ka\u0161el, pyrexie, tremor, pr\u016Fjem a enur\u00E9za.\n"@cs .