"4.6\tT\u011Bhotenstv\u00ED a kojen\u00ED"@cs . "004.006" . "T\u011Bhotenstv\u00ED\nO\u00A0pod\u00E1v\u00E1n\u00ED vinorelbinu t\u011Bhotn\u00FDm \u017Een\u00E1m nejsou k\u00A0dispozici dostate\u010Dn\u00E9 \u00FAdaje. V\u00A0reproduk\u010Dn\u00EDch studi\u00EDch u\u00A0zv\u00ED\u0159at bylo prok\u00E1z\u00E1no, \u017Ee m\u00E1 vinorelbin let\u00E1ln\u00ED a teratogenn\u00ED \u00FA\u010Dinky na embryo/plod. \u017Deny by b\u011Bhem l\u00E9\u010Dby vinorelbinem nem\u011Bly ot\u011Bhotn\u011Bt. Tento p\u0159\u00EDpravek nesm\u00ED b\u00FDt pod\u00E1v\u00E1n b\u011Bhem t\u011Bhotenstv\u00ED, nen\u00ED-li jasn\u011B indikov\u00E1n. Pokud k\u00A0ot\u011Bhotn\u011Bn\u00ED dojde v\u00A0pr\u016Fb\u011Bhu l\u00E9\u010Dby, doporu\u010Duje se genetick\u00E9 poradenstv\u00ED.\n\u017Deny ve fertiln\u00EDm v\u011Bku mus\u00ED b\u011Bhem l\u00E9\u010Dby a je\u0161t\u011B t\u0159i m\u011Bs\u00EDce po jej\u00EDm ukon\u010Den\u00ED pou\u017E\u00EDvat \u00FA\u010Dinnou antikoncepci a m\u011Bly by informovat l\u00E9ka\u0159e, pokud ot\u011Bhotn\u00ED.\nVinorelbin m\u016F\u017Ee vykazovat genotoxick\u00E9 \u00FA\u010Dinky. Z\u00A0tohoto d\u016Fvodu se mu\u017E\u016Fm l\u00E9\u010Den\u00FDm vinorelbinem doporu\u010Duje, aby b\u011Bhem l\u00E9\u010Dby a je\u0161t\u011B \u0161est m\u011Bs\u00EDc\u016F po ukon\u010Den\u00ED terapie nepo\u010Dali d\u00EDt\u011B.\nKojen\u00ED\nNen\u00ED zn\u00E1mo, zda se vinorelbin vylu\u010Duje do lidsk\u00E9ho mate\u0159sk\u00E9ho ml\u00E9ka, a proto mus\u00ED b\u00FDt kojen\u00ED p\u0159ed zah\u00E1jen\u00EDm l\u00E9\u010Dby t\u00EDmto p\u0159\u00EDpravkem p\u0159eru\u0161eno.\n"@cs . . . . . . .