. . "Bezpe\u010Dnostn\u00ED profil ramiprilu + hydrochlorothiazidu zahrnuje ne\u017E\u00E1douc\u00ED \u00FA\u010Dinky, kter\u00E9 se vyskytuj\u00ED ve spojen\u00ED s hypotenz\u00ED a/nebo s odvodn\u011Bn\u00EDm kv\u016Fli zv\u00FD\u0161en\u00E9 diur\u00E9ze. L\u00E9\u010Div\u00E1 l\u00E1tka ramipril m\u016F\u017Ee vyvolat p\u0159etrv\u00E1vaj\u00EDc\u00ED such\u00FD ka\u0161el, zat\u00EDmco hydrochlorothiazid m\u016F\u017Ee zhor\u0161it metabolismus glukosy, lipid\u016F a kyseliny mo\u010Dov\u00E9. Tyto dv\u011B l\u00E9\u010Div\u00E9 l\u00E1tky maj\u00ED inverzn\u00ED vliv na hladinu drasl\u00EDku v\u00A0s\u00E9ru. K\u00A0z\u00E1va\u017En\u00FDm ne\u017E\u00E1douc\u00EDm \u00FA\u010Dink\u016Fm pat\u0159\u00ED angioed\u00E9m anebo anafylaktick\u00E9 reakce, poruchy funkce ledvin nebo jater, pankreatitida, z\u00E1va\u017En\u00E9 ko\u017En\u00ED reakce a neutrop\u00E9nie/agranulocyt\u00F3za.\nFrekvence ne\u017E\u00E1douc\u00EDch \u00FA\u010Dink\u016F se definuje podle n\u00E1sleduj\u00EDc\u00ED konvence:\nVelmi \u010Dast\u00E9 ((1/10)\n\u010Cast\u00E9 ((1/100 a\u017E <1/10)\nM\u00E9n\u011B \u010Dast\u00E9 ((1/1000 a\u017E <1/100)\nVz\u00E1cn\u00E9 ((1/10000 a\u017E <1/1000)\nVelmi vz\u00E1cn\u00E9 (<1/10000), nen\u00ED zn\u00E1mo (z\u00A0dostupn\u00FDch \u00FAdaj\u016F nelze ur\u010Dit)\nV\u00A0ka\u017Ed\u00E9 skupin\u011B \u010Detnost\u00ED jsou ne\u017E\u00E1douc\u00ED \u00FA\u010Dinky se\u0159azeny podle klesaj\u00EDc\u00ED z\u00E1va\u017Enosti.\n\t\n\t\u010Cast\u00E9\n\tM\u00E9n\u011B \u010Dast\u00E9\n\tVelmi vz\u00E1cn\u00E9\n\tS nezn\u00E1mou frekvenc\u00ED\n\tSrde\u010Dn\u00ED poruchy\n\t\n\tSrde\u010Dn\u00ED ischemie v\u010Detn\u011B anginy pectoris, tachykardie, arytmie, palpitace, perifern\u00ED ed\u00E9m\n\t\n\tInfarkt myokardu\n\tPoruchy krve a lymfatick\u00E9ho syst\u00E9mu\n\t\n\tSn\u00ED\u017Een\u00FD po\u010Det b\u00EDl\u00FDch krvinek, sn\u00ED\u017Een\u00FD po\u010Det \u010Derven\u00FDch krvinek, pokles hemoglobinu, hemolytick\u00E1 an\u00E9mie, sn\u00ED\u017Een\u00FD po\u010Det krevn\u00EDch desti\u010Dek\n\t\n\tSelh\u00E1n\u00ED kostn\u00ED d\u0159en\u011B, neutropenie v\u010Detn\u011B agranulocyt\u00F3zy, pancytopenie, eozinofilie Hemokoncentrace v\u00A0souvislosti se ztr\u00E1tou tekutin\n\tPoruchy nervov\u00E9ho syst\u00E9mu\n\tBolest hlavy, z\u00E1vrat\u011B\n\tVertigo, parest\u00E9zie, tremor, poruchy rovnov\u00E1hy, pocit p\u00E1len\u00ED, dysgeuzie, ageuzie\n\t\n\tMozkov\u00E1 isch\u00E9mie v\u010Detn\u011B mozkov\u00E9 p\u0159\u00EDhody a tranzitorn\u00ED ischemick\u00E9 ataky, zhor\u0161en\u00E9 psychomotorick\u00E9 schopnosti, parosmie\n\tPoruchy oka\n\t\n\tPoruchy zraku v\u010Detn\u011B rozmazan\u00E9ho vid\u011Bn\u00ED, konjunktivitida \n\t\n\tXanthopsie, zv\u00FD\u0161en\u00E9 slzen\u00ED zp\u016Fsoben\u00E9 hydrochlorothiazidem\n\tPoruchy ucha a labyrintu\n\t\n\tTinitus\n\t\n\tZhor\u0161en\u00FD sluch\n\tRespira\u010Dn\u00ED, hrudn\u00ED a mediastin\u00E1ln\u00ED poruchy \n\tNeproduktivn\u00ED dr\u00E1\u017Ediv\u00FD ka\u0161el, bronchitida, \n\tSinusitida, dyspnoe, nepr\u016Fchodn\u00FD nos\n\t\n\tBronchospasmus v\u010Detn\u011B zhor\u0161en\u00ED astmatu\nAlergick\u00E1 alveolitida, nekardiogenn\u00ED plicn\u00ED ed\u00E9m n\u00E1sledkem p\u016Fsoben\u00ED hydrochlorothiazidu\n\tGastrointestin\u00E1ln\u00ED poruchy\n\t\n\tGastrointestin\u00E1ln\u00ED z\u00E1n\u011Bt, poruchy tr\u00E1ven\u00ED, b\u0159i\u0161n\u00ED obt\u00ED\u017Ee, dyspepsie, gastritida, nevolnost, z\u00E1cpa\nGingivitida n\u00E1sledkem p\u016Fsoben\u00ED hydrochlorothiazidu\n\tZvracen\u00ED, aftov\u00E1 stomatitida, glositida, pr\u016Fjem, bolest v\u00A0horn\u00ED \u010D\u00E1sti b\u0159icha, sucho v \u00FAstech\n\tPankreatitida (p\u0159i u\u017E\u00EDv\u00E1n\u00ED ACE inhibitor\u016F byly velmi v\u00FDjime\u010Dn\u011B hl\u00E1\u0161eny p\u0159\u00EDpady s\u00A0fat\u00E1ln\u00EDm pr\u016Fb\u011Bhem), zv\u00FD\u0161en\u00ED pankreatick\u00FDch enzym\u016F, angioed\u00E9m tenk\u00E9ho st\u0159eva\nSialoadenitida n\u00E1sledkem p\u016Fsoben\u00ED hydrochlorothiazidu\n\tPoruchy ledvin a\u00A0mo\u010Dov\u00FDch cest\n\t\n\tZhor\u0161en\u00ED funkce ledvin v\u010Detn\u011B akutn\u00EDho ren\u00E1ln\u00EDho selh\u00E1n\u00ED, zv\u00FD\u0161en\u00E9 vylu\u010Dov\u00E1n\u00ED mo\u010De, zv\u00FD\u0161en\u00ED mo\u010Doviny v\u00A0krvi, zv\u00FD\u0161en\u00ED kreatininu v\u00A0krvi\n\t\n\tZhor\u0161en\u00ED ji\u017E existuj\u00EDc\u00ED proteinurie\nInterstici\u00E1ln\u00ED nefritida jako n\u00E1sledek p\u016Fsoben\u00ED hydrochlorothiazidu\n\tPoruchy k\u016F\u017Ee a podko\u017En\u00ED tk\u00E1n\u011B\n\t\n\tAngioed\u00E9m; velmi v\u00FDjime\u010Dn\u011B m\u016F\u017Ee b\u00FDt obstrukce d\u00FDchac\u00EDch cest v\u00A0d\u016Fsledku angioed\u00E9mu fat\u00E1ln\u00ED; psoriatiformn\u00ED dermatitida, hyperhidr\u00F3za, vyr\u00E1\u017Eka, zejm\u00E9na makulopapul\u00E1rn\u00ED, pruritus, alopecie\n\t\n\tToxick\u00E1 epiderm\u00E1ln\u00ED nekrol\u00FDza, Stevens- Johnson\u016Fv syndrom, erythema multiforme, pemfigus, zhor\u0161en\u00ED psori\u00E1zy, exfoliativn\u00ED dermatitida, reakce z\u00A0p\u0159ecitliv\u011Blosti na sv\u011Btlo, onychol\u00FDza, pemfigoidn\u00ED nebo lichenoidn\u00ED exant\u00E9m nebo enant\u00E9m, kop\u0159ivka\nSyst\u00E9mov\u00FD lupus erythematosus n\u00E1sledkem p\u016Fsoben\u00ED hydrochlorothiazidu.\n\tPoruchy svalov\u00E9 a kostern\u00ED soustavy a pojivov\u00E9 tk\u00E1n\u011B\n\t\n\tMyalgie\n\t\n\tArtralgie, svalov\u00FD spasmus\nSvalov\u00E1 slabost, muskuloskelet\u00E1ln\u00ED strnulost, tetanus zp\u016Fsoben\u00FD hydrochlorothiazidem\n\tPoruchy metabolismu a v\u00FD\u017Eivy\n\tNedostate\u010Dn\u011B kontrolovan\u00FD diabetes mellitus, pokles tolerance glukosy, vzr\u016Fst glukosy v\u00A0krvi, vzr\u016Fst kyseliny mo\u010Dov\u00E9 v\u00A0krvi, zhor\u0161en\u00ED dny, zv\u00FD\u0161en\u00E9 hladiny cholesterolu a/nebo triglycerid\u016F v\u00A0krvi n\u00E1sledkem p\u016Fsoben\u00ED hydrochlorothiazidu\n\tAnorexie, sn\u00ED\u017Een\u00E1 chu\u0165 k\u00A0j\u00EDdlu\nSn\u00ED\u017Een\u00E1 hladina drasl\u00EDku v\u00A0krvi, \u017E\u00EDze\u0148 zp\u016Fsoben\u00E1 hydrochlorothiazidem\n\tZv\u00FD\u0161en\u00E1 hladina drasl\u00EDku v\u00A0krvi zp\u016Fsoben\u00E1 ramiprilem\n\tSn\u00ED\u017Een\u00E1 hladina sod\u00EDku v\u00A0krvi\nGlykosurie, metabolick\u00E1 alkal\u00F3za, hypochlor\u00E9mie, hypomagnez\u00E9mie, hyperkalc\u00E9mie, dehydratace zp\u016Fsoben\u00E1 hydrochlorothiazidem\n\tC\u00E9vn\u00ED poruchy\n\t\n\tHypotenze, sn\u00ED\u017Een\u00FD ortostatick\u00FD krevn\u00ED tlak, synkopa, zrudnut\u00ED \n\t\n\tTromb\u00F3za v\u00A0souvislosti se z\u00E1va\u017Enou ztr\u00E1tou tekutin, vaskul\u00E1rn\u00ED sten\u00F3za, hypoperfuze, Raynaud\u016Fv fenom\u00E9n, vaskulitida\n\tCelkov\u00E9 poruchy a reakce v\u00A0m\u00EDst\u011B aplikace\n\t\u00DAnava, astenie\n\tBolest na hrudn\u00EDku, pyrexie\n\t\n\t\n\tPoruchy imunitn\u00EDho syst\u00E9mu\n\t\n\t\n\t\n\tAnafylaktick\u00E9 nebo anafylaktoidn\u00ED reakce zp\u016Fsoben\u00E9 kteroukoli z\u00A0obou l\u00E9\u010Div\u00FDch l\u00E1tek nebo anafylaktick\u00E1 reakce zp\u016Fsoben\u00E1 hydrochlorothiazi-dem, zv\u00FD\u0161en\u00E9 antinukle\u00E1rn\u00ED protil\u00E1tky\n\tPoruchy jater a \u017Elu\u010Dov\u00FDch cest\n\t\n\tCholestatick\u00E1 nebo cytolytick\u00E1 hepatitida (velmi v\u00FDjime\u010Dn\u011B s fat\u00E1ln\u00EDm pr\u016Fb\u011Bhem), zv\u00FD\u0161en\u00E9 hladiny jatern\u00EDch enzym\u016F a/nebo konjugovan\u00E9ho bilirubinu\nKalkul\u00F3zn\u00ED cholecystitida zp\u016Fsoben\u00E1 hydrochlorothia-zidem\n\t\n\tAkutn\u00ED selh\u00E1n\u00ED jater, cholestatick\u00E1 \u017Eloutenka, hepatocelul\u00E1rn\u00ED po\u0161kozen\u00ED\n\tPoruchy reproduk\u010Dn\u00EDho syst\u00E9mu a prs\u016F\n\t\n\tP\u0159echodn\u00E1 erektiln\u00ED impotence\n\t\n\tPokles libida, gynekomastie\n\tPsychiatrick\u00E9 poruchy\n\t\n\tZhor\u0161en\u00E1 n\u00E1lada, apatie, \u00FAzkost, nervozita, poruchy sp\u00E1nku v\u010Detn\u011B somnolence\n\t\n\tStav zmatenosti, neklid, poruchy pozornosti\n"@cs . . . "Ne\u017E\u00E1douc\u00ED \u00FA\u010Dinky"@cs . "004.008" . . .