. . "4.5 \tInterakce s\u00A0jin\u00FDmi l\u00E9\u010Div\u00FDmi p\u0159\u00EDpravky a jin\u00E9 formy interakce"@cs . "004.005" . . . . . . . . . "Kontraindikovan\u00E9 kombinace\nMimot\u011Bln\u00ED l\u00E9\u010Dba vedouc\u00ED ke kontaktu krve s\u00A0negativn\u011B nabit\u00FDmi povrchy, jako nap\u0159. dial\u00FDza nebo hemofiltrace p\u0159i pou\u017Eit\u00ED n\u011Bkter\u00FDch vysoce propustn\u00FDch dialyza\u010Dn\u00EDch membr\u00E1n (nap\u0159. polyakrylonitrilov\u00E9 membr\u00E1ny), a afer\u00E9za lipoprotein\u016F s\u00A0n\u00EDzkou denzitou se sulf\u00E1tem dextranu z\u00A0d\u016Fvodu zv\u00FD\u0161en\u00E9ho rizika z\u00E1va\u017En\u00FDch anafylaktoidn\u00EDch reakc\u00ED (viz bod 4.3). P\u0159i l\u00E9\u010Db\u011B tohoto typu je nutn\u00E9 uv\u00E1\u017Eit pou\u017Eit\u00ED jin\u00E9ho typu dialyza\u010Dn\u00ED membr\u00E1ny, nebo l\u00E9\u010Div\u00E9ho p\u0159\u00EDpravku z\u00A0jin\u00E9 skupiny antihypertenziv.\nUpozorn\u011Bn\u00ED pro pou\u017Eit\u00ED\nSoli drasl\u00EDku, heparin, kalium \u0161et\u0159\u00EDc\u00ED diuretika a dal\u0161\u00ED p\u0159\u00EDpravky zvy\u0161uj\u00EDc\u00ED hladinu drasl\u00EDku v\u00A0plazm\u011B (v\u010Detn\u011B antagonist\u016F angiotenzinu II, trimetoprimu, takrolimu, cyklosporinu): M \u016F\u017Ee se vyskytnout hyperkal\u00E9mie, proto se vy\u017Eaduje sledov\u00E1n\u00ED hladiny drasl\u00EDku v\u00A0s\u00E9ru.\nAntihypertenziva (nap\u0159. diuretika) a jin\u00E9 l\u00E1tky sni\u017Euj\u00EDc\u00ED krevn\u00ED tlak (nap\u0159. nitr\u00E1ty, tricyklick\u00E1 antidepresiva, anestetika, akutn\u00ED po\u017Eit\u00ED alkoholu, baklofen, alfuzosin, doxazosin, prazosin, tamsulosin,terazosin ): Je t\u0159eba o\u010Dek\u00E1vat zv\u00FD\u0161en\u00ED rizika hypotenze (viz bod 4.2 pro diuretika).\nVasopresorick\u00E1 sympatomimetika a dal\u0161\u00ED l\u00E9ky (nap\u0159. izoproterenol, dobutamin, dopamin, epinefrin) , kter\u00E9 mohou sni\u017Eovat antihypertenzn\u00ED \u00FA\u010Dinek p\u0159\u00EDpravku Hartil: Doporu\u010Duje se sledovat krevn\u00ED tlak.\nAlopurinol, imunosupresiva, kortikosteroidy, prokainamid, cytostatika a dal\u0161\u00ED l\u00E1tky, kter\u00E9 mohou m\u011Bnit po\u010Det krvinek : Zv\u00FD\u0161en\u00E1 pravd\u011Bpodobnost hematologick\u00FDch reakc\u00ED (viz bod 4.4).\nSoli lithia : ACE inhibitory mohou sni\u017Eovat vylu\u010Dov\u00E1n\u00ED lithia, a proto m\u016F\u017Ee b\u00FDt toxicita lithia vy\u0161\u0161\u00ED. Proto je t\u0159eba sledovat hladinu lithia.\nAntidiabetika v\u010Detn\u011B inzul\u00EDnu : Mohou se vyskytnout hypoglykemick\u00E9 reakce. Doporu\u010Duje se sledovat hladinu gluk\u00F3zy v\u00A0krvi.\nNesteroidn\u00ED protiz\u00E1n\u011Btliv\u00E9 l\u00E1tky a kyselina acetylsalicylov\u00E1 : Je t\u0159eba o\u010Dek\u00E1vat oslaben\u00ED antihypertenzn\u00EDho \u00FA\u010Dinku p\u0159\u00EDpravku Hartil. Sou\u010Dasn\u00E9 pod\u00E1n\u00ED ACE inhibitor\u016F a NSAID m\u016F\u017Ee mimoto v\u00E9st ke zv\u00FD\u0161en\u00E9mu riziku zhor\u0161en\u00ED ren\u00E1ln\u00EDch funkc\u00ED a ke zv\u00FD\u0161en\u00ED hladiny drasl\u00EDku v\u00A0krvi.\n"@cs . .