<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-51> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-53> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-41> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-43> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-45> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-47> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-60> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasSectionTitle>	"4.5 \tInterakce s jin\u00FDmi l\u00E9\u010Div\u00FDmi p\u0159\u00EDpravky a jin\u00E9 formy interakce"@cs .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-8> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasText>	"Interakce spojen\u00E9 s valsartanem a hydrochlorothiazidem\nSoub\u011B\u017En\u00E9 pou\u017Eit\u00ED nen\u00ED doporu\u010Deno\nLithium\nReverzibiln\u00ED vzr\u016Fst koncentrac\u00ED lithia v s\u00E9ru a toxicita byly zaznamen\u00E1ny b\u011Bhem soub\u011B\u017En\u00E9ho pou\u017Eit\u00ED s inhibitory ACE a thiazidy, v\u010Detn\u011B hydrochlorothiazidu. Vzhledem k tomu, \u017Ee neexistuje dostatek zku\u0161enost\u00ED se soub\u011B\u017En\u00FDm pou\u017Eit\u00EDm valsartanu a lithia, nen\u00ED tato kombinace doporu\u010Dena. Pokud je pou\u017Eit\u00ED t\u00E9to kombinace nezbytn\u00E9, je doporu\u010Deno d\u016Fsledn\u011B monitorovat hladiny lithia v s\u00E9ru.\nP\u0159i soub\u011B\u017En\u00E9m pou\u017Eit\u00ED je vy\u017Eadov\u00E1na opatrnost\nJin\u00E1 antihypertenziva\nP\u0159\u00EDpravek Blessin\u00A0Plus\u00A0H m\u016F\u017Ee zesilovat \u00FA\u010Dinek jin\u00FDch antihypertenzn\u00EDch l\u00E1tek (nap\u0159. ACEI, betablok\u00E1tory, blok\u00E1tory v\u00E1pn\u00EDkov\u00FDch kan\u00E1l\u016F).\nVasopresorick\u00E9 aminy (nap\u0159. noradrenalin, adrenalin)\nJe mo\u017En\u00E1 sn\u00ED\u017Een\u00E1 reakce na vasopresorick\u00E9 aminy, ale nikoliv dostate\u010Dn\u011B na to, aby to vylou\u010Dilo jejich pou\u017Eit\u00ED.\nNesteroidn\u00ED protiz\u00E1n\u011Btliv\u00E9 l\u00E9ky (NSAIDs=non-steroidal anti- inflammatory drugs), v\u010Detn\u011B selektivn\u00EDch\ninhibitor\u016F COX-2, kyseliny acetylsalicylov\u00E9 >3\u00A0g/denn\u011B a neselektivn\u00EDch NSAIDs\nNSAIDs mohou sn\u00ED\u017Eit antihypertenzn\u00ED \u00FA\u010Dinek jak antagonist\u016F angiotensinu II, tak hydrochlorothiazidu, pokud jsou pod\u00E1v\u00E1ny sou\u010Dasn\u011B. Sou\u010Dasn\u00E9 pod\u00E1v\u00E1n\u00ED p\u0159\u00EDpravku Blessin\u00A0Plus\u00A0H a NSAIDs m\u016F\u017Ee nav\u00EDc v\u00E9st ke zhor\u0161en\u00ED ren\u00E1ln\u00EDch funkc\u00ED a zv\u00FD\u0161en\u00ED s\u00E9rov\u00E9 hladiny drasl\u00EDku. Proto je na za\u010D\u00E1tku l\u00E9\u010Dby doporu\u010Deno monitorov\u00E1n\u00ED funkce ledvin stejn\u011B tak jako dostate\u010Dn\u00E1 hydratace pacienta.\nInterakce t\u00FDkaj\u00EDc\u00ED se valsartanu\nSoub\u011B\u017En\u00E9 pou\u017Eit\u00ED nen\u00ED doporu\u010Deno\nDiuretika \u0161et\u0159\u00EDc\u00ED drasl\u00EDk, suplementy obsahuj\u00EDc\u00ED drasl\u00EDk, n\u00E1hrady soli obsahuj\u00EDc\u00ED drasl\u00EDk a jin\u00E9 l\u00E1tky,\nkter\u00E9 mohou zvy\u0161ovat hladiny drasl\u00EDku\nPokud je u\u017E\u00EDv\u00E1n\u00ED l\u00E9\u010Div\u00E9ho p\u0159\u00EDpravku, kter\u00FD ovliv\u0148uje hladiny drasl\u00EDku, v kombinaci s\u00A0valsartanem nezbytn\u00E9, je doporu\u010Deno monitorovat hladiny drasl\u00EDku v plazm\u011B.\n\u017D\u00E1dn\u00E9 interakce\nVe studi\u00EDch l\u00E9kov\u00FDch interakc\u00ED s valsartanem nebyly nalezeny klinicky signifikantn\u00ED interakce valsartanu s n\u00E1sleduj\u00EDc\u00EDmi l\u00E1tkami: cimetidin, warfarin, furosemid, digoxin, atenolol, indometacin, hydrochlorothiazid, amlodipin a glibenklamid. Digoxin a indometacin mohou interagovat s hydrochlorothiazidovou slo\u017Ekou p\u0159\u00EDpravku Blessin\u00A0Plus\u00A0H (viz interakce t\u00FDkaj\u00EDc\u00ED se hydrochlorothiazidu).\nInterakce t\u00FDkaj\u00EDc\u00ED se hydrochlorothiazidu\nP\u0159i soub\u011B\u017En\u00E9m pou\u017Eit\u00ED je vy\u017Eadov\u00E1na opatrnost\nL\u00E9\u010Div\u00E9 p\u0159\u00EDpravky spojen\u00E9 se ztr\u00E1tou drasl\u00EDku a hypokalemi\u00ED\n(nap\u0159. kalium-deple\u010Dn\u00ED diuretika, kortikosteroidy, laxativa, ACTH, amfotericin, karbenoxolon, penicilin G, kyselina salicylov\u00E1 a deriv\u00E1ty). Pokud jsou tyto l\u00E9\u010Div\u00E9 p\u0159\u00EDpravky p\u0159edepisov\u00E1ny spolu s kombinac\u00ED hydrochlorothiazid-valsartan, doporu\u010Duje se monitorov\u00E1n\u00ED s\u00E9rov\u00FDch hladin drasl\u00EDku. Tyto l\u00E9\u010Div\u00E9 p\u0159\u00EDpravky mohou potencovat \u00FA\u010Dinek hydrochlorothiazidu na s\u00E9rov\u00FD drasl\u00EDk (viz bod 4.4).\nL\u00E9\u010Div\u00E9 p\u0159\u00EDpravky, kter\u00E9 mohou zp\u016Fsobit torsades de pointes\nAntiarytmika t\u0159\u00EDdy Ia (nap\u0159. chinidin, hydrochinidin, disopyramid)\nAntiarytmika t\u0159\u00EDdy III (nap\u0159. amiodaron, sotalol, dofetilid, ibutilid)\nN\u011Bkter\u00E1 antipsychotika (nap\u0159i. thioridazin, chlorpromazin, levomepromazin, trifluoperazin, cyamemazin, sulpirid, sultoprid, amisulprid, tiaprid, pimozid, haloperidol, droperidol)\nJin\u00E9 l\u00E1tky (nap\u0159. bepridil, cisaprid, difemanil, erytromycin i.v., halofantrin, ketanserin, mizolastin, pentamidin, sparfloxacin, terfenadin, vinkamin i.v.)\nVzhledem k riziku hypokalemie by m\u011Bl b\u00FDt hydrochlorothiazid pod\u00E1v\u00E1n s opatrnost\u00ED, pokud je pod\u00E1v\u00E1n soub\u011B\u017En\u011B s l\u00E9\u010Div\u00FDmi p\u0159\u00EDpravky, kter\u00E9 mohou zp\u016Fsobovat torsades de pointes.\nDigitalisov\u00E9 glykosidy\nThiazidy indukovan\u00E1 hypokalemie \u010Di hypomagnezemie se mohou objevit jako ne\u017E\u00E1douc\u00ED \u00FA\u010Dinky zvy\u0161uj\u00EDc\u00ED v\u00FDskyt srde\u010Dn\u00EDch arytmi\u00ED zp\u016Fsoben\u00FDch digitalisem.\nSoli v\u00E1pn\u00EDku a vitam\u00EDn D\nPod\u00E1n\u00ED thiazidov\u00FDch diuretik, v\u010Detn\u011B hydrochlorothiazidu, spolu s vitam\u00EDnem D nebo solemi v\u00E1pn\u00EDku m\u016F\u017Ee potencovat vzestup s\u00E9rov\u00FDch hladin v\u00E1pn\u00EDku.\nAntidiabetika (peror\u00E1ln\u00ED l\u00E1tky a inzulin)\nL\u00E9\u010Dba thiazidov\u00FDmi diuretiky m\u016F\u017Ee ovlivnit glukosovou toleranci. Mohou b\u00FDt zapot\u0159eb\u00ED \u00FApravy d\u00E1vek antidiabetick\u00FDch l\u00E9k\u016F.\nS ohledem na riziko mo\u017En\u00E9ho funk\u010Dn\u00EDho ren\u00E1ln\u00EDho selh\u00E1n\u00ED spojen\u00E9ho s hydrochlorothiazidem by m\u011Bl b\u00FDt metformin pou\u017E\u00EDv\u00E1n pouze s opatrnost\u00ED kv\u016Fli riziku lakt\u00E1tov\u00E9 acid\u00F3zy.\nBetablok\u00E1tory a diazoxid\nSou\u010Dasn\u00E9 pou\u017Eit\u00ED thiazidov\u00FDch diuretik, v\u010Detn\u011B hydrochlorothiazidu, s betablok\u00E1tory m\u016F\u017Ee zv\u00FD\u0161it riziko hyperglykemie. Thiazidov\u00E1 diuretika, v\u010Detn\u011B hydrochlorothiazidu, mohou zvy\u0161ovat hyperglykemizuj\u00EDc\u00ED \u00FA\u010Dinek diazoxidu.\nL\u00E9\u010Debn\u00E9 p\u0159\u00EDpravky pou\u017E\u00EDvan\u00E9 v l\u00E9\u010Db\u011B dny (probenecid, sulfinpyrazon a alopurinol)\nM\u016F\u017Ee b\u00FDt zapot\u0159eb\u00ED \u00FAprava d\u00E1vky urikosurik, proto\u017Ee hydrochlorothiazid m\u016F\u017Ee zvy\u0161ovat hladiny s\u00E9rov\u00E9 kyseliny mo\u010Dov\u00E9. Zv\u00FD\u0161en\u00ED d\u00E1vky probenecidu a sulfinpyrazonu m\u016F\u017Ee b\u00FDt t\u00E9\u017E zapot\u0159eb\u00ED. Sou\u010Dasn\u00E9 pod\u00E1v\u00E1n\u00ED thiazidov\u00FDch diuretik, v\u010Detn\u011B hydrochlorothiazidu, m\u016F\u017Ee zv\u00FD\u0161it incidenci hypersenzitivity k alopurinolu.\nAnticholinergn\u00ED l\u00E1tky (nap\u0159. atropin, biperiden)\nBiologick\u00E1 dostupnost thiazidov\u00FDch diuretik m\u016F\u017Ee b\u00FDt zv\u00FD\u0161ena anticholinergn\u00EDmi l\u00E1tkami, z\u0159ejm\u011B v d\u016Fsledku sn\u00ED\u017Een\u00E9 gastrointestin\u00E1ln\u00ED motility a rychlosti vyprazd\u0148ov\u00E1n\u00ED \u017Ealudku.\nAmantadin\nThiazidy, v\u010Detn\u011B hydrochlorothiazidu, mohou zv\u00FD\u0161it riziko ne\u017E\u00E1douc\u00EDch \u00FA\u010Dink\u016F amantadinu.\nPrysky\u0159ice cholestyraminu a kolestipolu\nAbsorpce thiazidov\u00FDch diuretik, v\u010Detn\u011B hydrochlorothiazidu, je zhor\u0161ena v p\u0159\u00EDtomnosti anionick\u00FDch iontom\u011Bni\u010D\u016F.\nCytotoxick\u00E9 l\u00E1tky (nap\u0159. cyklofosfamid, metotrex\u00E1t)\nThiazidy, v\u010Detn\u011B hydrochlorothiazidu, mohou sni\u017Eovat ren\u00E1ln\u00ED exkreci cytotoxick\u00FDch l\u00E1tek a potencovat tak jejich myelosupresivn\u00ED \u00FA\u010Dinek.\nNedepolarizuj\u00EDc\u00ED perifern\u00ED myorelaxancia (nap\u0159. tubokurarin)\nThiazidy, v\u010Detn\u011B hydrochlorothiazidu, potencuj\u00ED \u00FA\u010Dinek deriv\u00E1t\u016F kurare.\nCyklosporin\nSou\u010Dasn\u00E1 l\u00E9\u010Dba cyklosporinem m\u016F\u017Ee zv\u00FD\u0161it riziko hyperurikemie a komplikac\u00ED typu dny.\nAlkohol, anestetika a sedativa\nM\u016F\u017Ee doj\u00EDt k potenciaci ortostatick\u00E9 hypotenze.\nMetyldopa\nExistuj\u00ED izolovan\u00E1 hl\u00E1\u0161en\u00ED v\u00FDskytu hemolytick\u00E9 anemie u pacient\u016F l\u00E9\u010Den\u00FDch sou\u010Dasn\u011B metyldopou a hydrochlorothiazidem.\nKarbamazepin\nU pacient\u016F u\u017E\u00EDvaj\u00EDc\u00EDch hydrochlorothiazid sou\u010Dasn\u011B s karbamazepinem m\u016F\u017Ee doj\u00EDt k\u00A0rozvoji hyponatremie. Tito pacienti by m\u011Bli b\u00FDt o mo\u017Enosti vzniku hyponatremie pou\u010Deni a m\u011Bli by b\u00FDt odpov\u00EDdaj\u00EDc\u00EDm zp\u016Fsobem sledov\u00E1n\u00ED.\nJodov\u00E9 kontrastn\u00ED l\u00E1tky\nV p\u0159\u00EDpad\u011B diuretiky indukovan\u00E9 dehydratace existuje zv\u00FD\u0161en\u00E9 riziko akutn\u00EDho ren\u00E1ln\u00EDho selh\u00E1n\u00ED, p\u0159edev\u0161\u00EDm u vysok\u00FDch d\u00E1vek jodov\u00FDch l\u00E1tek. Pacienti by m\u011Bli b\u00FDt p\u0159ed pod\u00E1n\u00EDm rehydratov\u00E1ni.\n"@cs .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-1> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-55> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-10> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-57> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-12> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-58> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-23> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-59> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-24> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-30> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-32> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasOrderNumber>	"004.005" .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-13> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-18> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-19> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-20> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-38> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-39> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-4> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-40> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-34> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-35> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-36> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-37> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://www.w3.org/1999/02/22-rdf-syntax-ns#type>	<http://salt.semanticauthoring.org/ontologies/sdo#Section> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-49> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://www.w3.org/1999/02/22-rdf-syntax-ns#type>	<http://linked.opendata.cz/ontology/spc/InteractionSection> .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC118958_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC118958_doc-4-5-5> .