"Ne\u017E\u00E1douc\u00ED \u00FA\u010Dinky"@cs . "004.008" . "Gastrointestin\u00E1ln\u00ED poruchy : jako je nausea, zvracen\u00ED, pr\u016Fjem, bolesti b\u0159icha a nechutenstv\u00ED (>10%) jsou velmi \u010Dast\u00E9: zejm\u00E9na se objevuj\u00ED b\u011Bhem zah\u00E1jen\u00ED l\u00E9\u010Dby a v\u011Bt\u0161inou ust\u00E1vaj\u00ED spont\u00E1nn\u011B. K\u00A0p\u0159edch\u00E1zen\u00ED t\u011Bchto gastrointestin\u00E1ln\u00EDch symptom\u016F se doporu\u010Duje u\u017E\u00EDvat metformin ve 2 a\u017E 3 denn\u00EDch d\u00E1vk\u00E1ch b\u011Bhem j\u00EDdla nebo po j\u00EDdle. Pomal\u00E9 zvy\u0161ov\u00E1n\u00ED d\u00E1vky m\u016F\u017Ee tak\u00E9 zlep\u0161it gastrointestin\u00E1ln\u00ED tolerabilitu.\nKovov\u00E1 pachu\u0165 (3%) je b\u011B\u017En\u00E1.\nU n\u011Bkter\u00FDch hypersenzitivn\u00EDch osob byl pops\u00E1n slab\u00FD eryt\u00E9m. Incidence tohoto \u00FA\u010Dinku je velmi n\u00EDzk\u00E1 (<0,01%).\nU pacient\u016F l\u00E9\u010Den\u00FDch metforminem dlouhodob\u011B byla pozorov\u00E1na sn\u00ED\u017Een\u00E1 absorpce vitam\u00EDnu B12 s\u00A0jeho sn\u00ED\u017Eenou hladinou v\u00A0plazm\u011B, v\u011Bt\u0161inou bez klinick\u00E9ho v\u00FDznamu (<0,01%).\nLakt\u00E1tov\u00E1 acid\u00F3za (0,03 p\u0159\u00EDpady/1000 pacient\u016F a rok) je velmi vz\u00E1cn\u00E1 (viz 4.4 Zvl\u00E1\u0161tn\u00ED upozorn\u011Bn\u00ED a zvl\u00E1\u0161tn\u00ED opat\u0159en\u00ED p\u0159i u\u017E\u00EDv\u00E1n\u00ED).\n"@cs . . . . . . .