. . . " Interakce s\u00A0jin\u00FDmi l\u00E9\u010Div\u00FDmi p\u0159\u00EDpravky a jin\u00E9 formy interakce"@cs . . . . . . . "Soub\u011B\u017En\u00E9 pod\u00E1n\u00ED glukokortikoid\u016F anebo dal\u0161\u00EDch NSAID zvy\u0161uje riziko krv\u00E1cen\u00ED do gastrointestin\u00E1ln\u00EDho traktu (GIT) a riziko vzniku ulcerac\u00ED.\nP\u0159i sou\u010Dasn\u00E9m pod\u00E1v\u00E1n\u00ED NSAID a antikoagulanci\u00ED, nap\u0159. warfarinu, doch\u00E1z\u00ED k\u00A0prodlou\u017Een\u00ED protrombinov\u00E9ho \u010Dasu a zv\u00FD\u0161en\u00E9mu riziku krv\u00E1cen\u00ED. \nSoub\u011B\u017En\u00E9 pod\u00E1v\u00E1n\u00ED antiagrega\u010Dn\u00EDch l\u00E1tek nebo SSRI zvy\u0161uje riziko gastrointestin\u00E1ln\u00EDho krv\u00E1cen\u00ED.\nPreklinick\u00E9 \u00FAdaje poukazuj\u00ED na to, \u017Ee ibuprofen p\u0159i sou\u010Dasn\u00E9m pod\u00E1v\u00E1n\u00ED s n\u00EDzkod\u00E1vkovanou kyselinou acetylsalicylovou (ASA) m\u016F\u017Ee tlumit jej\u00ED vliv na agregaci desti\u010Dek. Tyto \u00FAdaje v\u0161ak maj\u00ED sv\u00E9 limity a nen\u00ED zn\u00E1m jejich dopad na klinickou praxi. Zejm\u00E9na p\u0159i ojedin\u011Bl\u00E9m kr\u00E1tkodob\u00E9m pod\u00E1v\u00E1n\u00ED ibuprofenu nen\u00ED klinicky v\u00FDznamn\u00FD vliv pravd\u011Bpodobn\u00FD (viz 5.1).\nFenobarbital zrychluje metabolizaci ibuprofenu. \nIbuprofen zvy\u0161uje plazmatick\u00E9 hladiny lithia, digoxinu a fenytoinu, zvy\u0161uje toxicitu metotrex\u00E1tu a baklofenu. Soub\u011B\u017En\u00E9 pod\u00E1n\u00ED kalium \u0161et\u0159\u00EDc\u00EDch diuretik m\u016F\u017Ee v\u00E9st k\u00A0hyperkal\u00E9mii. P\u0159i soub\u011B\u017En\u00E9m pod\u00E1v\u00E1n\u00ED ibuprofenu s\u00A0deriv\u00E1ty sulfonylmo\u010Doviny u pacient\u016F s\u00A0diabetes melitus m\u016F\u017Ee snadn\u011Bji doj\u00EDt k\u00A0projev\u016Fm hypoglykemie. Z\u00E1sahem ibuprofenu do synt\u00E9zy prostaglandin\u016F v ledvin\u00E1ch by mohlo doj\u00EDt ke zv\u00FD\u0161en\u00ED nefrotoxicity cyklosporinu.\nIbuprofen sni\u017Euje urikosurick\u00FD \u00FA\u010Dinek probenecidu a sulfinpyrazonu. Je mo\u017En\u00E9 sn\u00ED\u017Een\u00ED \u00FA\u010Dinku diuretik a antihypertonik.\nP\u0159i soub\u011B\u017En\u00E9m pod\u00E1n\u00ED ibuprofenu a takrolimu je zv\u00FD\u0161eno riziko nefrotoxicity.\nP\u0159i soub\u011B\u017En\u00E9m pod\u00E1n\u00ED ibuprofenu a zidovudinu je zv\u00FD\u0161en\u00E9 riziko hemartrosu a hematomu u HIV pozitivn\u00EDch pacient\u016F s hemofili\u00ED.\n"@cs . . . "004.005" .