<http://linked.opendata.cz/resource/sukl/spc/section/SPC102160_doc-5-1>	<http://salt.semanticauthoring.org/ontologies/sdo#hasText>	"Farmakoterapeutick\u00E1 skupina: ATC k\u00F3d G03C A03\nP\u0159\u00EDrodn\u00ED a polosyntetick\u00E9 estrogeny, jednoduch\u00E9 (k vagin\u00E1ln\u00EDmu pou\u017Eit\u00ED).\n\u00DA\u010Dinn\u00E1 l\u00E1tka, syntetick\u00FD 17(-estradiol, je chemicky a biologicky toto\u017En\u00FD s endogenn\u00EDm lidsk\u00FDm estradiolem.\nEndogenn\u00ED 17(-estradiol vyvol\u00E1v\u00E1 a udr\u017Euje prim\u00E1rn\u00ED a sekund\u00E1rn\u00ED \u017Eensk\u00E9 pohlavn\u00ED znaky. Biologick\u00FD \u00FA\u010Dinek 17(-estradiolu prob\u00EDh\u00E1 na \u0159ad\u011B specifick\u00FDch estrogenov\u00FDch receptor\u016F. Komplex steroidn\u00EDch receptor\u016F je v\u00E1z\u00E1n na bun\u011B\u010Dnou DNA a indukuje synt\u00E9zu specifick\u00FDch protein\u016F.\nZr\u00E1n\u00ED po\u0161evn\u00EDho epitelu je z\u00E1visl\u00E9 na estrogenu. Estrogen zvy\u0161uje po\u010Det superfici\u00E1ln\u00EDch a intermedi\u00E1ln\u00EDch bun\u011Bk ve srovn\u00E1n\u00ED s baz\u00E1ln\u00EDmi bu\u0148kami.\nEstrogen sni\u017Euje po\u0161evn\u00ED pH na p\u0159ibli\u017En\u011B 4,5, co\u017E podporuje norm\u00E1ln\u00ED bakteri\u00E1ln\u00ED fl\u00F3ru, v n\u00ED\u017E p\u0159evl\u00E1d\u00E1 Lactobacillus Doderleini.\n"@cs .
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