<http://linked.opendata.cz/resource/sukl/spc/section/SPC100736_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasOrderNumber>	"004.005" .
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<http://linked.opendata.cz/resource/sukl/spc/section/SPC100736_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasSectionTitle>	"4.5.  Interakce s\u00A0jin\u00FDmi l\u00E9\u010Div\u00FDmi p\u0159\u00EDpravky a jin\u00E9 formy interakce"@cs .
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<http://linked.opendata.cz/resource/sukl/spc/section/SPC100736_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC100736_doc-4-5-27> .
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<http://linked.opendata.cz/resource/sukl/spc/section/SPC100736_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasText>	"Kontraindikovan\u00E9 kombinace:\n- Floktafenin\nV\u00A0p\u0159\u00EDpadech  floktafeninem vyvolan\u00E9ho \u0161oku nebo hypotenze betablok\u00E1tory sni\u017Euj\u00ED schopnost kompenza\u010Dn\u00ED reakce.\n- Sultoprid\nPoruchy srde\u010Dn\u00ED automacie  (excesivn\u00ED bradykardie) dan\u00E9 spole\u010Dn\u00FDm bradykardizuj\u00EDc\u00EDm \u00FA\u010Dinkem.\nNedoporu\u010Den\u00E9 kombinace:\n- amiodaron\nNebezpe\u010D\u00ED poruch kontraktility, srde\u010Dn\u00ED automacie a veden\u00ED (potla\u010Den\u00EDm sympatick\u00E9ho kompenza\u010Dn\u00EDho mechanismu).\n - srde\u010Dn\u00ED glykosidy \nKombinace, kter\u00E9 mohou prodlu\u017Eovat dobu atrioventrikul\u00E1rn\u00EDho veden\u00ED a v\u00E9st k bradykardii.\nKombinace, vy\u017Eaduj\u00EDc\u00ED zvl\u00E1\u0161tn\u00ED opatrnost:\nT\u011Bkav\u00E1 halogenovan\u00E1 anestetika \n\u00DF-blok\u00E1tory naru\u0161uj\u00ED srde\u010Dn\u00ED kompenza\u010Dn\u00ED mechanismy. (K potla\u010Den\u00ED betalytick\u00E9ho efektu se m\u016F\u017Ee b\u011Bhem v\u00FDkonu podat betamimetikum). \nNedoporu\u010Duje se v\u0161ak p\u0159eru\u0161it pod\u00E1v\u00E1n\u00ED \u00DF-blok\u00E1toru. Anesteziolog mus\u00ED b\u00FDt informov\u00E1n o skute\u010Dnosti, \u017Ee pacient je l\u00E9\u010Den betalytikem.\nBlok\u00E1tory kalciov\u00E9ho kan\u00E1lu (bepridil, diltiazem, verapamil a mibefradil):\nPoruchy srde\u010Dn\u00ED automacie (excesivn\u00ED bradykardie, sinusov\u00E1 z\u00E1stava), poruchy sinoatri\u00E1ln\u00EDho nebo atriventrikul\u00E1rn\u00EDho veden\u00ED a srde\u010Dn\u00ED selh\u00E1n\u00ED (synergick\u00FD efekt).\n- Antiarytmika (propafenon a t\u0159\u00EDda Ia: quinidin, hydroquinidin a disopyramid):\nPoruchy srde\u010Dn\u00ED automacie a poruchy veden\u00ED (potla\u010Den\u00ED sympatick\u00E9ho kompenza\u010Dn\u00EDho mechanismu).\nBaklofen:\nZv\u00FD\u0161en\u00FD antihypertenzn\u00ED \u00FA\u010Dinek.\nM\u011Bl by b\u00FDt sledov\u00E1n krevn\u00ED tlak a v\u00A0p\u0159\u00EDpad\u011B nutnosti upravena d\u00E1vka antihypertenziva.\nInzul\u00EDn a hypoglykemick\u00E9 sulfonamidy (viz 4.4  upozorn\u011Bn\u00ED):\nV\u0161echny betablok\u00E1tory zast\u00EDraj\u00ED ur\u010Dit\u00E9 symptomy hypoglyk\u00E9mie, nap\u0159. palpitace a tachykardii.\nPacient mus\u00ED b\u00FDt o t\u00E9to skute\u010Dnosti informov\u00E1n a mus\u00ED b\u00FDt pou\u010Den o nutnosti sledovat hladinu krevn\u00EDho cukru v krat\u0161\u00EDch intervalech, zvl\u00E1\u0161t\u011B na za\u010D\u00E1tku l\u00E9\u010Dby.\nLidokain:\nInterakce popsan\u00E9 s\u00A0propanololem, metorpololem a nadololem:\nZv\u00FD\u0161en\u00ED plazmatick\u00E9 koncentrace lidokainu s\u00A0mo\u017En\u00FDm zv\u00FD\u0161en\u00EDm neurologick\u00FDch a srde\u010Dn\u00EDch ne\u017E\u00E1douc\u00EDch \u00FA\u010Dink\u016F (sn\u00ED\u017Een\u00FD metabolismus lidokainu v\u00A0j\u00E1trech).\nD\u00E1vka lidokainu by m\u011Bla b\u00FDt upravena. B\u011Bhem l\u00E9\u010Dby betablok\u00E1tory a po jej\u00EDm p\u0159eru\u0161en\u00ED by m\u011Blo b\u00FDt prov\u00E1d\u011Bno klinick\u00E9 a elektrokardiografick\u00E9 sledov\u00E1n\u00ED a sledov\u00E1n\u00ED plazmatick\u00E9 koncentrace lidokainu.\nKontrastn\u00ED l\u00E1tky obsahuj\u00EDc\u00ED j\u00F3d:\nV\u00A0p\u0159\u00EDpadech \u0161oku nebo hypotenze z\u00A0d\u016Fvod\u016F aplikace kontrastn\u00EDch l\u00E1tek obsahuj\u00EDc\u00EDch j\u00F3d,  betablok\u00E1tory zp\u016Fsobuj\u00ED sn\u00ED\u017Een\u00ED kardiovaskul\u00E1rn\u00EDch kompenza\u010Dn\u00EDch reakc\u00ED.\nPokud je to mo\u017En\u00E9, l\u00E9\u010Dba betablok\u00E1tory by m\u011Bla b\u00FDt p\u0159eru\u0161ena p\u0159ed radiografick\u00FDm kontrastn\u00EDm vy\u0161et\u0159en\u00EDm. Pokud je nezbytn\u00E1  l\u00E9\u010Dba betablok\u00E1tory bez p\u0159eru\u0161en\u00ED, m\u011Blo by vy\u0161et\u0159en\u00ED b\u00FDt provedeno jen s\u00A0mo\u017Enost\u00ED zaji\u0161t\u011Bn\u00ED na  jednotce intenz\u00EDvn\u00ED p\u00E9\u010De.\nKombinace, kter\u00E9 je t\u0159eba vz\u00EDt v\u00A0\u00FAvahu:\nNesteroidn\u00ED antiflogistika \nSn\u00ED\u017Een\u00ED antihypertenzn\u00EDho \u00FA\u010Dinku (inhibice vasodilata\u010Dn\u00EDch prostaglandin\u016F nesteroidn\u00EDmi antiflogistiky a hromad\u011Bn\u00ED vody a sod\u00EDku s\u00A0NSAID-pyrazolonov\u00FDmi deriv\u00E1ty).\nBlok\u00E1tory kalciov\u00E9ho kan\u00E1lu:  dihydropyridiny jako nifendipin\nHypotenze, srde\u010Dn\u00ED selh\u00E1n\u00ED u pacient\u016F s\u00A0latentn\u00EDm nebo nedostate\u010Dn\u011B kontrolovan\u00FDm srde\u010Dn\u00EDm selh\u00E1n\u00EDm (negativn\u011B ionotropn\u00ED efekt dihydropyridin\u016F in vitro li\u0161\u00EDc\u00ED se podle p\u0159\u00EDslu\u0161n\u00E9ho p\u0159\u00EDpravku a pravd\u011Bpodobn\u011B p\u0159id\u00E1vaj\u00EDc\u00ED se k\u00A0ionotropn\u00EDmu \u00FA\u010Dinku betablok\u00E1tor\u016F). L\u00E9\u010Dba betablok\u00E1tory m\u016F\u017Ee tak\u00E9 minimalizovat reflexn\u00ED reakci sympatiku po  excesivn\u00ED hemodynamick\u00E9 z\u00E1t\u011B\u017Ei.\nTricyklick\u00E1 antidepresiva p\u0159\u00EDbuzn\u00E1 s\u00A0imipraminem, neuroleptika:\nZv\u00FD\u0161en\u00ED antihypertenzn\u00EDho \u00FA\u010Dinku a riziko postur\u00E1ln\u00ED hypotenze (aditivn\u00ED \u00FA\u010Dinek).\nKortikosteroidy a tetrakosaktidy\nSn\u00ED\u017Een\u00ED antihypertenzn\u00EDho \u00FA\u010Dinku (retence vody a natria)\nMefloquin\nRiziko bradykardie (s\u010D\u00EDt\u00E1n\u00ED bradykardizuj\u00EDc\u00EDho efektu).\nSympatomimetika\nRiziko sn\u00ED\u017Een\u00ED \u00FA\u010Dinku betablok\u00E1tor\u016F.\n"@cs .
<http://linked.opendata.cz/resource/sukl/spc/section/SPC100736_doc-4-5>	<http://salt.semanticauthoring.org/ontologies/sdo#hasParagraph>	<http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC100736_doc-4-5-17> .