. . . "Dimetacrine"@en . . . . . . "Approximately 10 hours. (PMID 5312397)"@en . "Humans and other mammals"@en . . "Dimetacrine may induce severe cardiac toxicity in overdose. This property is unique among the tricyclic antidepressants. "@en . "Linostil"@en . . "4757-55-5"@en . "Miroistonil"@en . . "# http://worldwide.espacenet.com/publicationDetails/biblio?CC=GB&NR=933875&KC=&FT=E&locale=en_EP"@en . "The highest concentrations of dimetacrine were found at 1 hour after administration but at 3 hours in brain, heart, lung, liver, spleen, kidney, skeletal muscle and adipose tissue of testes. (Carried out in mice, PMID 5312397). "@en . . . " "@en . "Dimetacrine (Istonil, Istonyl, Linostil, Miroistonil), also known as dimethacrine and acripramine, is a tricyclic antidepressant (TCA) with imipramine-like effects used in Europe and formerly in Japan for the treatment of depression. "@en . . . "approved"@en . . "Approximately 70% of the doses were excreted in urine and feces within 2 days after treatment. (PMID 5312397)"@en . . . . "withdrawn"@en . . . "# Ishitani R, Saito E, Kitagawa H: The pharmacological studies on dimetacrine. I. Studies on the absorption, distribution and excretion of H3-labeled dimetacrine in the rat. Jpn J Pharmacol. 1970 Sep;20(3):432-8. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/5312397"@en . . "Istonil"@en . . . "3-(9,9-dimethylacridin-10-yl)-N,N-dimethyl-propan-1-amine"@en . . . . . . . . . "Istonyl"@en . . . "Dimetacrine"@en . .