. . . . . "Ruxolitinib"@en . . . . "INCB018424"@en . . "Eliminated via urine (74%, <1% as unchanged drug) and feces (22%, <1% as unchanged drug). "@en . . . "Ruxolitinib is a janus-associated kinase inhibitor indicated to treat bone marrow cancer, specifically intermediate or high-risk myelofibrosis. FDA approved on November 16, 2011. "@en . . . . . . . . . . . "INCB424"@en . "# Cervantes F, Martinez-Trillos A: Myelofibrosis: an update on current pharmacotherapy and future directions. Expert Opin Pharmacother. 2013 May;14(7):873-84. doi: 10.1517/14656566.2013.783019. Epub 2013 Mar 21. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/23514013 # Lexi-Comp, Inc. (Lexi-DrugsTM ). Lexi-Comp, Inc.; July, 2013. # Yang LP, Keating GM: Ruxolitinib: in the treatment of myelofibrosis. Drugs. 2012 Nov 12;72(16):2117-27. doi: 10.2165/11209340-000000000-00000. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/23061804"@en . . . . . . . "Terminal phase volume of distribution, 15 mg, healthy subject = 76.6 L."@en . . . . . . "approved"@en . . "Ruxolitinib is a kinase inhibitor that is selective for the Janus Associated Kinases (JAK) 1 and 2. These kinases are responsible for the mediation of cytokine and growth factor signalling which in turn effect immune function and hematopoiesis. The signalling process involves signal transducers and transcription activators (STAT) which modulate gene expression. Patients with myelofibrosis have abnormal JAK1 and JAK2 activity thus ruxolitinib works to regulate this. "@en . . . " "@en . . . . "Mean elimination half-life, 15 mg, healthy subject = 2.8 hours. "@en . "Treatment of intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera (post-PV) myelofibrosis and post-essential thrombocythemia (post-ET) myelofibrosis. [Lexicomp] Myeolofibrosis is the proliferation of abnormal bone marrow stem cells which cause fibrosis (the excessive formation of connective tissue)."@en . . "Thrombocytopenia was the dose-limiting toxicity. "@en . . . "Absorption is rapid and is not affected by food. Cmax, 15 mg, healthy subject = 649 nmol/L; Tmax, 15 mg, healthy subject = 1.5 hours; Ruxolitinib does not accumulate significantly. "@en . . "Humans and other mammals"@en . "15 mg, healthy subject = 18.7 L/h. "@en . "Take without regards to meals "@en . "941678-49-5"@en . "97% protein bound, primarily to albumin. "@en . . . .