. "Taliglucerase Alfa"@en . "Taliglucerase alfa is administered IV so absorption is 100%."@en . "The half life is between 18.9 to 28.7 min."@en . "Route of elimination was not determined."@en . . "Humans and other mammals"@en . "Taliglucerase alfa is the recombinant active form of the human lysosomal enzyme, \u03B2-glucocerebrosidase. It was approved in 2012 and is marketed under the name Elelyso for use in patients with type 1 Gaucher's disease."@en . . . . . "Taliglucerase alfa is different from human glucocerebrosidase by two amino acids at the N terminal and up to 7 amino acids at the C terminal. This recombinant enzyme allows the hydrolysis reaction of glucocerebroside to glucose and ceramide that naturally occurs in healthy individuals."@en . "The most common toxic reaction seen was infusion reactions such as urticaria, arthralgia, headache, and chest pain due to IV administration."@en . . . "No food effects found."@en . "approved"@en . "For the treatment of adult Type 1 Gaucher disease. "@en . " "@en . . "# Zimran A, Brill-Almon E, Chertkoff R, Petakov M, Blanco-Favela F, Munoz ET, Solorio-Meza SE, Amato D, Duran G, Giona F, Heitner R, Rosenbaum H, Giraldo P, Mehta A, Park G, Phillips M, Elstein D, Altarescu G, Szleifer M, Hashmueli S, Aviezer D: Pivotal trial with plant cell-expressed recombinant glucocerebrosidase, taliglucerase alfa, a novel enzyme replacement therapy for Gaucher disease. Blood. 2011 Nov 24;118(22):5767-73. doi: 10.1182/blood-2011-07-366955. Epub 2011 Sep 6. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/21900191 # Aviezer D, Brill-Almon E, Shaaltiel Y, Hashmueli S, Bartfeld D, Mizrachi S, Liberman Y, Freeman A, Zimran A, Galun E: A plant-derived recombinant human glucocerebrosidase enzyme--a preclinical and phase I investigation. PLoS One. 2009;4(3):e4792. doi: 10.1371/journal.pone.0004792. Epub 2009 Mar 11. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/19277123 "@en . "37228-64-1"@en . "The steady state volume of distribution is between 7.30 to 11.7 L."@en . "prGCD"@en . . . "The systemic clearance was approximately 30 L/hr and 20 L/hr for 30 and 60 units/kg, respectively."@en . . . "Plasma protein binding was not quantified."@en . "Shaaltiel Y, Bartfeld D, Hashmueli S, Baum G, Brill-Almon E, Galili G, Dym O, Boldin-Adamsky SA, Silman I, Sussman JL, Futerman AH, Aviezer D: Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system. Plant Biotechnol J. 2007 Sep;5(5):579-90. Epub 2007 May 24."@en .