. . . . "Mafenide is a sulfonamide-type medication used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns. "@en . " "@en . "Bensulfamide"@en . . "Mafenide"@en . . . "4-Homosufanilamide"@en . "Renal\u2014Metabolite rapidly excreted in urine in high concentrations; however, the parent compound has not been detected in urine. "@en . . "approved"@en . . "Since mafenide is metabolized to a carbonic anhydrase inhibitor, metabolic acidosis could occur. Mafenide is contraindicated in persons with renal impairment or sulfonamide hypersensitivity."@en . . . . . . . "Pseudomonas aeruginosa"@en . "U.S. Patent 2,288,531."@en . . . . . . "Mafenide is absorbed through devascularized areas into the systemic circulation following topical administration."@en . . . . . . . "Mafenide is indicated in the treatment of severe burns."@en . . . "4-(aminomethyl)benzenesulfonamide"@en . . . . "# Maghsoudi H, Salehi F, Khosrowshahi MK, Baghaei M, Nasirzadeh M, Shams R: Comparison between topical honey and mafenide acetate in treatment of burn wounds. Ann Burns Fire Disasters. 2011 Sep 30;24(3):132-7. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/22396671"@en . "The precise mechanism of mafenide is unknown. However, mafenide reduces the bacterial population in the avascular burn tissue and promotes spontaneous heeling of deep burns. "@en . "Gram negative and gram positive bacteria"@en . "Maphenidum"@en . "138-39-6"@en . "Bacteria"@en . . . . . . .