. . . . . . . "Difluprednate is a topical corticosteroid indicated for the treatment of infammation and pain associated with ocular surgery. It is a butyrate ester of 6(\u03B1), 9(\u03B1)-difluoro prednisolone acetate. Difluprednate is abbreviated DFBA, or difluoroprednisolone butyrate acetate. It is indicated for treatment of endogenous anterior uveiti. "@en . "Corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins (lipocortins). It is postulated that these proteins control the biosynthesis of potent mediators of infammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2."@en . "approved"@en . . . . . . . . . "Preclinical pharmacokinetic and toxicity studies have established that difluprednate ophthalmic emulsion 0.05% given 4 times a day is not toxic to the eye."@en . . . "DFBA"@en . . "Durezol"@en . . . . . "Humans and other mammals"@en . . "78.5% of radioactivity was excreted aftert 24 hours, and 99.5% by 7 days after a single dose of labeled difluprednate instilled in the right eyes of pigmented rabbits."@en . . . . . . . "Ercoli, A. and Gardi, R.; U.S. Patent 3,780,177; December 18,1973; assigned to Warner-Lambert Co."@en . . . . . " "@en . . "23674-86-4"@en . . . "For the treatment of inflammation and pain associated with ocular surgery."@en . . "Difluoroprednisolone butyrate acetate"@en . "Difluprednate"@en . . . . . . . "# Korenfeld MS, Silverstein SM, Cooke DL, Vogel R, Crockett RS: Difluprednate ophthalmic emulsion 0.05% for postoperative inflammation and pain. J Cataract Refract Surg. 2009 Jan;35(1):26-34. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/19101421 # Jamal KN, Callanan DG: The role of difluprednate ophthalmic emulsion in clinical practice. Clin Ophthalmol. 2009;3:381-90. Epub 2009 Jun 29. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/19668594 # https://online.epocrates.com/u/10a4844/Durezol # Morton KD, Van de Kar LD, Brownfield MS, Bethea CL: Neuronal cell bodies in the hypothalamic paraventricular nucleus mediate stress-induced renin and corticosterone secretion. Neuroendocrinology. 1989 Jul;50(1):73-80. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/2666872"@en . "Difluprednate penetrates the corneal epithelium rapidly and effectively. Low systemic absorption. "@en . .