. . "At low doses, OPC 28326 selectively vasodilates the femoral arterial bed due to its inhibitory action at alpha-2-adrenoceptors while having minimal action on systemic blood pressure, heart rate and coronary, carotid, vertebral, renal, and mesenteric blood flows. It is the only clinical compound with this profile. It is currently being investigated in the treatment of peripheral vascular diseases and Raynaud's syndrome."@en . . "investigational"@en . . . . . "10 mg and 40 mg was well tolerated during clinical trials with Raynaud's patients"@en . . "At low doses, OPC 28326 selectively vasodilates the femoral arterial bed due to its inhibitory action at alpha-2C-adrenoceptors. Other studies have also reported selectivity for a-2B-adrenoceptors."@en . . . . "Investigated for use/treatment in peripheral vascular disease and raynaud's disease."@en . . . . . . . . . "OPC-28326"@en . "# Sumi M, Sata M, Hashimoto A, Imaizumi T, Yanaga K, Ohki T, Mori T, Nagai R: OPC-28326, a selective femoral arterial vasodilator, augments ischemia induced angiogenesis. Biomed Pharmacother. 2007 May;61(4):209-15. Epub 2006 Dec 28. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/17223008 # Wise RA, Wigley FM, White B, Leatherman G, Zhong J, Krasa H, Kambayashi J, Orlandi C, Czerwiec FS: Efficacy and tolerability of a selective alpha(2C)-adrenergic receptor blocker in recovery from cold-induced vasospasm in scleroderma patients: a single-center, double-blind, placebo-controlled, randomized crossover study. Arthritis Rheum. 2004 Dec;50(12):3994-4001. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/15593189 # Orito K, Imaizumi T, Yoshida K, Kishi M, Fujiki H, Mori T: Effect of oral OPC-28326, a selective femoral arterial vasodilator, on hindlimb subcutaneous tissue temperature in conscious dogs under buprenorphine sedation. Jpn J Pharmacol. 2002 Jan;88(1):119-22. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/11855671 # Orito K, Kishi M, Imaizumi T, Nakazawa T, Hashimoto A, Mori T, Kambe T: alpha(2)-adrenoceptor antagonist properties of OPC-28326, a novel selective peripheral vasodilator. Br J Pharmacol. 2001 Oct;134(4):763-70. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/11606316 # Orito K, Imaizumi T, Yoshida K, Fujiki H, Kishi M, Teramoto S, Tanaka M, Shimizu H, Tominaga M, Kimura Y, Kambayashi J, Mori T: Mechanisms of action of OPC-28326, a selective hindlimb vasodilator. J Pharmacol Exp Ther. 1999 Nov;291(2):604-11. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/10525078 # Sun B, Lockyer S, Li J, Chen R, Yoshitake M, Kambayashi JI: OPC-28326, a selective femoral vasodilator, is an alpha2C-adrenoceptor-selective antagonist. J Pharmacol Exp Ther. 2001 Nov;299(2):652-8. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/11602678"@en . . . . . . . . . .