. . "Oxypurinol inhibits the enzyme xanthine oxidase, blocking the conversion of the oxypurines hypoxanthine and xanthine to uric acid. Elevated concentrations of oxypurine and oxypurine inhibition of xanthine oxidase through negative feedback results in a decrease in the concentrations of uric acid in the blood and urine. Oxypurinol also facilitates the incorporation of hypoxanthine and xanthine into DNA and RNA, resulting in further reductions of serum uric acid concentrations."@en . "Oxypurinol, an inhibitor of xanthine oxidase, is a metabolite of allopurinol."@en . . . . "23.3 +/- 6.0 hours"@en . . "investigational"@en . "1H-Pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione"@en . "Humans and other mammals"@en . " "@en . "Oxipurinol"@en . . . "6-hydroxy allopurinol"@en . . . "Oxipurinolum"@en . . . . "2465-59-0"@en . "Alloxanthin"@en . . "Oxoallopurinol"@en . "metabolite of allopurinol"@en . . . . . "Oxyprim"@en . . . . . "# Iwanaga T, Kobayashi D, Hirayama M, Maeda T, Tamai I: Involvement of uric acid transporter in increased renal clearance of the xanthine oxidase inhibitor oxypurinol induced by a uricosuric agent, benzbromarone. Drug Metab Dispos. 2005 Dec;33(12):1791-5. Epub 2005 Aug 31. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/16135657 # Baldus S, Koster R, Chumley P, Heitzer T, Rudolph V, Ostad MA, Warnholtz A, Staude HJ, Thuneke F, Koss K, Berger J, Meinertz T, Freeman BA, Munzel T: Oxypurinol improves coronary and peripheral endothelial function in patients with coronary artery disease. Free Radic Biol Med. 2005 Nov 1;39(9):1184-90. Epub 2005 Aug 10. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/16214034 # Reyes AJ, Leary WP: Allopurinol or oxypurinol in heart failure therapy - a promising new development or end of story? Cardiovasc Drugs Ther. 2005 Oct;19(5):311-3. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/16382292"@en . . . "1H-Pyrazolo[3,4-d]pyrimidine-4,6-diol"@en . . . . . . "Oxypurinol"@en . . . . . "Alloxanthine"@en . . "DHPP"@en . . "Intended for the treatment of congestive heart failure and hyperuricemia."@en .