. . "Flibanserin"@en . . . . . "Flibanserin is a drug produced by Boehringer Ingelheim. It is currently being investigated as a drug for women suffering from decreased sexual desire. It is a 5-HT1A serotonin receptor agonist that had initially been developed as an anti-depressant. [Wikipedia]"@en . . . . . . "BIMT-17-BS"@en . . . . . "167933-07-5"@en . . . . . . . . "BIMT-17"@en . . . . "# Invernizzi RW, Sacchetti G, Parini S, Acconcia S, Samanin R: Flibanserin, a potential antidepressant drug, lowers 5-HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: role of 5-HT(1A) receptors. Br J Pharmacol. 2003 Aug;139(7):1281-8. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/12890707 # Scandroglio A, Monferini E, Borsini F: Ex vivo binding of flibanserin to serotonin 5-HT1A and 5-HT2A receptors. Pharmacol Res. 2001 Feb;43(2):179-83. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/11243720 # Borsini F, Cesana R: Mechanism of action of flibanserin in the learned helplessness paradigm in rats. Eur J Pharmacol. 2001 Dec 14;433(1):81-9. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/11755137 # Borsini F, Evans K, Jason K, Rohde F, Alexander B, Pollentier S: Pharmacology of flibanserin. CNS Drug Rev. 2002 Summer;8(2):117-42. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/12177684"@en . . "For the treatment of sexual dysfunction in women."@en . "Flibanserin has preferential affinity for serotonin 5-HT(1A), dopamine D(4k), and serotonin 5-HT(2A) receptors. In vitro and in microiontophoresis, flibanserin behaves as a 5-HT(1A) agonist, a very weak partial agonist on dopamine D(4) receptors, and a 5-HT(2A) antagonist. In vivo flibanserin binds equally to 5-HT(1A) and 5-HT(2A) receptors. However, under higher levels of brain 5-HT (i.e., under stress), flibanserin may occupy 5-HT(2A) receptors in higher proportion than 5-HT(1A) receptors. "@en . . . "Humans and other mammals"@en . "Orally available. "@en . . . . . "investigational"@en . .