. . . . . . . . . . "Bicifadine (DOV-220075) is a nonopioid analgesic. It is an inhibitor of both the norepinephrine and serotonin transporters and an NMDA antagonist with a non-narcotic profile. Bicifadine was shown to have potent analgesic activity in vivo and was chosen for further development for the treatment of pain."@en . "71195-57-8"@en . . . . " "@en . "investigational"@en . . . "Bicifadine"@en . . . . . . . "Humans and other mammals"@en . "Preclinical studies and clinical trials indicate that bicifadine's analgesic properties result through the enhancement and prolongation of norepinephrine and serotonin actions, however other actions may be involved."@en . . . . "For the treatment of pain."@en . . . . . . . . "# Basile AS, Janowsky A, Golembiowska K, Kowalska M, Tam E, Benveniste M, Popik P, Nikiforuk A, Krawczyk M, Nowak G, Krieter PA, Lippa AS, Skolnick P, Koustova E: Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain. J Pharmacol Exp Ther. 2007 Jun;321(3):1208-25. Epub 2007 Feb 26. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/17325229 # Erickson DA, Hollfelder S, Tenge J, Gohdes M, Burkhardt JJ, Krieter PA: In Vitro Metabolism of the Analgesic Bicifadine in the Mouse, Rat, Monkey, and Human. Drug Metab Dispos. 2007 Sep 19;. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/17881661"@en . .