. "For the treatment of malaria. Also under investigation for the modulation of multidrug resistance in cancer cells."@en . "Plasmodium"@en . " "@en . "Methyl-12-methoxy-13-(17-methoxy-17-oxovobasan-3alpha-yl)ibogamine-18-carboxylate"@en . . . . "investigational"@en . "approved"@en . . . . "3371-85-5"@en . . . "Voacamine"@en . . . . "# Meschini S, Marra M, Condello M, Calcabrini A, Federici E, Dupuis ML, Cianfriglia M, Arancia G: Voacamine, an alkaloid extracted from Peschiera fuchsiaefolia, inhibits P-glycoprotein action in multidrug-resistant tumor cells. Int J Oncol. 2005 Dec;27(6):1597-603. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/16273216 # Meschini S, Condello M, Marra M, Formisano G, Federici E, Arancia G: Autophagy-mediated chemosensitizing effect of the plant alkaloid voacamine on multidrug resistant cells. Toxicol In Vitro. 2007 Mar;21(2):197-203. Epub 2006 Sep 16. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/17070665 # Meschini S, Marra M, Calcabrini A, Federici E, Galeffi C, Arancia G: Voacamine, a bisindolic alkaloid from Peschiera fuchsiaefolia, enhances the cytotoxic effect of doxorubicin on multidrug-resistant tumor cells. Int J Oncol. 2003 Dec;23(6):1505-13. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/14612920 "@en . . . . . . . . "Voacamine is possibly a substrate for P-glycoprotein (P-gp), an efflux pump responsible for multidrug resistance in tumor cells. Voacamine may compete with anticancer drugs such as doxorubicin for P-gp transport, decreasing removal of doxorubicin. "@en . . . . . . . . . "Voacamine is an alkaloid isolated from the bark of the Pescheria fuchsiae folia tree. It is an antimalarial drug approved for use in several African countries. Voacamine is also under investigation for use in modulating multidrug-resistance in tumor cells. "@en . . "Voacanginine"@en . . . . . . . . "Vocamine"@en .