. "Merimepodib"@en . . . . "198821-22-6"@en . . "# Markland W, McQuaid TJ, Jain J, Kwong AD: Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferon. Antimicrob Agents Chemother. 2000 Apr;44(4):859-66. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/10722482"@en . . . . . . . . "Merimepodib (VX-497) is a novel noncompetitive inhibitor of IMPDH. Merimepodib is orally bioavailable and inhibits the proliferation of primary human, mouse, rat, and dog lymphocytes at concentrations of approximately 100 nM."@en . . . . . . "investigational"@en . "Merimepodib is a orally active inhibitor of inosine monophospate dehydrogenase (IMPDH). IMPDH inhibition leads to a reduction in intracellular guanosine triphosphate (GTP), a molecule required for DNA and RNA synthesis."@en . . "MMPD"@en . "Hepatitis C virus, RSV and other RNA/DNA viruses"@en . . . . . . . . . . "For the treatment of hepatitis C virus (HCV) infection."@en . . . . . . .