"Avoid alcohol."@en . . . . "Aranya Manosroi, \"Synthesis of cyproterone acetate.\" U.S. Patent US20040024230, issued February 05, 2004."@en . . . . "Elimination Following oral or intramuscular administration, the plasma half-life is 38 and 96 hours, respectively."@en . . . . . . . . . . . . . . "investigational"@en . . . "approved"@en . "For the palliative treatment of patients with advanced prostatic carcinoma."@en . "# Giorgi EP, Shirley IM, Grant JK, Stewart JC: Androgen dynamics in vitro in the human prostate gland. Effect of cyproterone and cyproterone acetate. Biochem J. 1973 Mar;132(3):465-74. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/4125095 # Pham-Huu-Trung MT, de Smitter N, Bogyo A, Girard F: Effects of cyproterone acetate on adrenal steroidogenesis in vitro. Horm Res. 1984;20(2):108-15. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/6237971 # Stadtler FA, Langner V: The effect of cyproterone and gonadotrophins on the adrenal gland of juvenile and adult rats. A morphological and morphometrical study. Pathol Res Pract. 1985 Mar;179(4-5):493-8. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/4001026 # Honer C, Nam K, Fink C, Marshall P, Ksander G, Chatelain RE, Cornell W, Steele R, Schweitzer R, Schumacher C: Glucocorticoid receptor antagonism by cyproterone acetate and RU486. Mol Pharmacol. 2003 May;63(5):1012-20. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/12695529 # Holdaway IM, Croxson MS, Evans MC, France J, Sheehan A, Wilson T, Ibbertson HK: Effect of cyproterone acetate on glucocorticoid secretion in patients treated for hirsutism. Acta Endocrinol (Copenh). 1983 Oct;104(2):222-6. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/6227191"@en . . . . . . "The direct antiandrogenic effect of cyproterone is blockage of the binding of dihydrotestosterone to the specific receptors in the prostatic carcinoma cell. In addition, cyproterone exerts a negative feed-back on the hypothalamo-pituitary axis, by inhibiting the secretion of luteinizing hormone resulting in diminished production of testicular testosterone."@en . . . . . "An anti-androgen that, in the form of its acetate (cyproterone acetate), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females. [Pubchem]"@en . . . . "Cyproterone 17-O-acetate"@en . . . . "Completely absorbed following oral administration."@en . "Cyproterone acetate"@en . "Take after a meal."@en . "Humans and other mammals"@en . "It is excreted approximately 60% in the bile and 33% through the kidneys."@en . "427-51-0"@en . .