"Naganol"@en . . . . . "A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties. Suramin is manufactured by Bayer in Germany as Germanin\u00AE."@en . . "approved"@en . "Suramin"@en . . "145-63-1"@en . . . . "Yeast, Molds, Trypanosomes"@en . " "@en . . . "8,8'-[CARBONYLBIS[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid"@en . . "The mechanism is unknown, but the trypanocidal activity may be due to the inhibition of enzymes involved with the oxidation of reduced nicotinamide-adenine dinucleotide (NADH), which functions as a co-enzyme in many cellular reactions, such as respiration and glycolysis, in the trypanosome parasite. Suramin's action in the treatment of onchocerciasis is macrofilaricidal and partially microfilaricidal. It may also act as an antagonist of P2 receptors and as an agonist of Ryanodine receptors. It also can inhibit follicle-stimulating hormone receptors."@en . . . "Suramin"@en . . "For treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms."@en . . . . "Approximately 99.7%"@en . . . . . . . . . . "Suramine"@en . . . . . "Poorly absorbed from the gastrointestinal tract."@en . "Approximately 36 to 60 days"@en . "Naphuride"@en . . . . . . " "@en . . . . "Belganyl"@en . .