"D-camptothecin"@en . . "21,22-Secocamptothecin-21-oic acid lactone"@en . "Camptothecine"@en . . . "Humans and other mammals"@en . "20(S)-Camptothecin"@en . . "Camptothecin binds to the topoisomerase I and DNA complex (the covalent complex) resulting in a ternary complex, and thereby stabilizing it. This prevents DNA relegation and therefore causes DNA damage which results in apoptosis."@en . . "# Wall ME, Wani MC: Camptothecin and taxol: from discovery to clinic. J Ethnopharmacol. 1996 Apr;51(1-3):239-53; discussion 253-4. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/9213622 # Kepler JA, Wani MC, McNaull JN, Wall ME, Levine SG: Plant antitumor agents. IV. An approach toward the synthesis of camptothecin. J Org Chem. 1969 Dec;34(12):3853-8. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/5357525"@en . . . . . . . . . . . . "Investigated for the treatment of cancer."@en . . . . . . . . . "Camptothecin"@en . . . . . . . "7689-03-4"@en . "An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity. [PubChem]"@en . . . . . . . . "experimental"@en . . "Acute oral toxicity (LD₅₀) in mouse: 50.1 mg/kg "@en . "(+)-camptothecine"@en . "Tadashi Miyasaka, Seigo Sawada, Kenichiro Nokata, Masahiko Mutai, \"Photochemical process for preparing camptothecin derivatives.\" U.S. Patent US4545880, issued March, 1976."@en . . . . "(s)-camptothecin"@en . "(+)-camptothecin"@en . "(s)-(+)-camptothecin"@en . " "@en .