. . "L-valine, ester with ganciclovir"@en . . "Valganciclovir is an antiviral medication used for the treatment of cytomegalovirus infections."@en . . "Valganciclovir is well absorbed from the gastrointestinal tract and the absolute bioavailability from valganciclovir tablets (following administration with food) is approximately 60%."@en . . . "The major route of elimination of valganciclovir is by renal excretion as ganciclovir through glomerular filtration and active tubular secretion."@en . "Romi Singh, Vishnubhotla Nagaprasad, Nidhi Singh, \"Processes for the Preparation of Solid Dosage Forms of Amorphous Valganciclovir Hydrochloride.\" U.S. Patent US20070292499, issued December 20, 2007."@en . "Valganciclovir"@en . . . . "It is expected that an overdose of valganciclovir could also possibly result in increased renal toxicity."@en . . "* 0.703 \u00B1 0.134 L/kg"@en . . . "Human Herpes Virus"@en . . . "Valcyte"@en . . . "Valganciclovir is a prodrug of ganciclovir that exists as a mixture of two diastereomers. After administration, these diastereomers are rapidly converted to ganciclovir by hepatic and intestinal esterases. In cytomegalovirus (CMV)-infected cells, ganciclovir is initially phosphorylated to the monophosphate form by viral protein kinase, then it is further phosphorylated via cellular kinases to produce the triphosphate form. This triphosphate form is slowly metabolized intracellularly. The phosphorylation is dependent upon the viral kinase and occurs preferentially in virus-infected cells. The virustatic activity of ganciclovir is due to the inhibition of viral DNA synthesis by ganciclovir triphosphate. Ganciclovir triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand. Ganciclovir inhibits viral DNA polymerases more effectively than it does cellular polymerase, and chain elongation resumes when ganciclovir is removed."@en . . . . . "Plasma protein binding of ganciclovir is 1% to 2% over concentrations of 0.5 and 51 mg/mL."@en . . . . . . . . "175865-60-8"@en . . . "Approximately 4.08 hours. Increased in patients with renal function impairment."@en . . " "@en . "investigational"@en . "Cymeval"@en . . . . . . . "# Umapathy NS, Ganapathy V, Ganapathy ME: Transport of amino acid esters and the amino-acid-based prodrug valganciclovir by the amino acid transporter ATB(0,+). Pharm Res. 2004 Jul;21(7):1303-10. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/15290873"@en . . . . . . "Valganciclovir"@en . . . . . . "Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases."@en . "* 3.07+/- 0.64 mL/min/kg [IV administration] * 5.3 L/hr [Patient with creatinine clearance of 70.4 mL/min]"@en . . . . . "approved"@en . . .