"6452-71-7"@en . . "Humans and other mammals"@en . "Avoid alcohol."@en . . . . . . . . "Oxprenolol"@en . . . . . "Avoid natural licorice."@en . . . " "@en . . . . . . "Oral bioavailability is 20-70%."@en . "# McDevitt DG: Comparison of pharmacokinetic properties of beta-adrenoceptor blocking drugs. Eur Heart J. 1987 Dec;8 Suppl M:9-14. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/2897304"@en . "Symptoms of overdose include abdominal irritation, central nervous system depression, coma, extremely slow heartbeat, heart failure, lethargy, low blood pressure, and wheezing."@en . . . . . . "Oxprenololum"@en . . "Used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety."@en . . . . . . . . "Take without regard to meals."@en . "1-2 hours"@en . . "approved"@en . "Oxprenolol"@en . "A beta-adrenergic antagonist used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety. [PubChem]"@en . . . . " "@en . "Like other beta-adrenergic antagonists, oxprenolol competes with adrenergic neurotransmitters such as catecholamines for binding at sympathetic receptor sites. Like propranolol and timolol, oxprenolol binds at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting the effects of the catecholamines epinephrine and norepinephrine and decreasing heart rate, cardiac output, and systolic and diastolic blood pressure. It also blocks beta-2 adrenergic receptors located in bronchiole smooth muscle, causing vasoconstriction. By binding beta-2 receptors in the juxtaglomerular apparatus, oxprenolol inhibits the production of renin, thereby inhibiting angiotensin II and aldosterone production. Oxprenolol therefore inhibits the vasoconstriction and water retention due to angiotensin II and aldosterone, respectively."@en . . . . . .