"Cloxazolam is a benzodiazepine with anxiolytic, sedative/hypnotic, muscle relaxant, and antiepileptic effects. [3] It is marketed in the Argentina, Australia, Portugal, Belgium, Switzerland, Luxembourg, Germany, Taiwan and Japan -- mainly for anti-anxiety. The usual dose of cloxazolam in adults is 3-12mg/day for anti-anxiety. [3] Although less commonly noted, it has also been reported as clinically effective in the treatment of depression, schizophrenia, and neurosis. [4] As well, it has also been studied in Japan in doses of 15-30mg/day as an adjunct in the treatment of intractable epilepsy, for which it has demonstrated effectiveness. [3]"@en . . "Tachikawa, R., Takagi, H., Kamioka, T., Fukunaga, M., Kawano, Y. and Miyadera, T.; US. Patents 3,696,094; October 3,1972; and 3,772,371; November 13, 1973; both assigned to Sankyo Company Limited, Japan."@en . "approved"@en . "Cloxazolam is a long acting benzodiazepine. It acts as a prodrug, with pharmacologically active metabolites, which bind to to the GABAa receptor, which other benzodiazepines bind to, to illicit a physiological response. [wiki] "@en . "24166-13-0"@en . . . . "1. Ansseau, Marc, and Remy von Frenckell. \"Controlled comparison of two anxiolytic benzodiazepines, cloxazolam and bromazepam.\" Neuropsychobiology 24.1 (1990): 25-29 2. Boucsein, W., and G. Wendt-Suhl. \"Psychological and physiological effects of cloxazolam and diazepam under anxiety-evoking and control conditions on healthy subjects (author's transl)].\" Pharmacopsychiatria 15.2 (1982): 48. 3. Ito, Masatoshi, et al. \"Cloxazolam treatment for patients with intractable epilepsy.\" Pediatric neurology 30.2 (2004): 111-114. 4. Murata, Hisashi, et al. \"Metabolism of Cloxazolam. I. Distribution, Excretion and Biotransformation in Rats and Mice.\" Chemical & pharmaceutical bulletin 21.2 (1973): 404-414. 5. Oliveira\u2010Silva, Diogo, et al. \"Quantification of chlordesmethyldiazepam by liquid chromatography\u2013tandem mass spectrometry: application to a cloxazolam bioequivalence study.\" Biomedical Chromatography 23.12 (2009): 1266-1275."@en . . . "Used primarily as an anti-anxiety agent. Typically used short term, and may be given as a single dose of up to 100mcg/kg to reduce anxiety and tension experienced prior to surgery. "@en . . . . "65 hours"@en . . " "@en . . "Cloxazolazepam "@en . . . "Alcohol used in combination may enhance sedation or cause potentially fatal respiratory/cardiovascular depression."@en . "MT 14-411 "@en . "Sepazon"@en . . . . "investigational"@en . . . . . . . . . "Drowsiness and ataxia are dose related. Central nervous system toxicity may result in respiratory depression and loss of consciousness. As such, pre-existing central nervous system depression and severe hepatic impairment are two particular contraindications for use."@en . . . "Renal elimination. "@en . . . . . . . . . . "Cloxazolam"@en . . . .