. . . . "Avoid excessive quantities of coffee or tea (Caffeine)."@en . . . . . . . . . "approved"@en . . . "Avoid alcohol."@en . "# Rickels K: The clinical use of hypnotics: indications for use and the need for a variety of hypnotics. Acta Psychiatr Scand Suppl. 1986;332:132-41. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/2883820 # Robertson MD, Drummer OH: Postmortem drug metabolism by bacteria. J Forensic Sci. 1995 May;40(3):382-6. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/7782744 # Oelschlager H: [Chemical and pharmacologic aspects of benzodiazepines] Schweiz Rundsch Med Prax. 1989 Jul 4;78(27-28):766-72. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/2570451 # Usami N, Yamamoto T, Shintani S, Ishikura S, Higaki Y, Katagiri Y, Hara A: Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines. Biol Pharm Bull. 2002 Apr;25(4):441-5. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/11995921 # Tokunaga S, Takeda Y, Shinomiya K, Hirase M, Kamei C: Effects of some H1-antagonists on the sleep-wake cycle in sleep-disturbed rats. J Pharmacol Sci. 2007 Feb;103(2):201-6. Epub 2007 Feb 8. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/17287588"@en . "For short-term treatment of severe insomnias, that are not responsive to other hypnotics."@en . "18-26 hours"@en . "Symptoms of overdose include confusion, coma, impaired coordination, sleepiness, and slowed reaction time."@en . . "Avoid taking with grapefruit juice."@en . . "illicit"@en . . . "Flunitrazepam"@en . . . "A benzodiazepine with pharmacologic actions similar to those of diazepam that can cause anterograde amnesia. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug. [PubChem]"@en . . . "Flunitrazepamum"@en . . "1622-62-4"@en . . "Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell."@en . " "@en . . . "Rohypnol"@en . . . . . . . "50% (suppository) and 64-77% (oral)"@en . "Kariss, J. and Newmark, H.L.; U.S. Patent 3,116,203; December 31, 1963; assigned to Hoffmann-la Roche Inc.\u2028 Kariss, J. and Newmark, H.L.; US. Patent 3,123,529; March 3,1964; assigned to Hoffmann-La Roche Inc. \u2028Keiler, O., Steiger, N. and Sternbach, L.H.; U.S. Patent 3,203,990; August 31, 1965; assigned to Hoffmann-La Roche Inc."@en . "Humans and other mammals"@en . . . . . "Take with food."@en . . . . .