"Dehydrospirorenone"@en . . . "Humans and other mammals"@en . "# Krattenmacher R: Drospirenone: pharmacology and pharmacokinetics of a unique progestogen. Contraception. 2000 Jul;62(1):29-38. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/11024226 # Wichianpitaya J, Taneepanichskul S: A comparative efficacy of low-dose combined oral contraceptives containing desogestrel and drospirenone in premenstrual symptoms. Obstet Gynecol Int. 2013;2013:487143. doi: 10.1155/2013/487143. Epub 2013 Feb 20. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/23577032"@en . . "Food reduces the rate of absorption, but not the extent of absorption. "@en . "6beta,7Beta;15beta,16beta-dimethylene-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone"@en . "30 hours"@en . "Drospirenona"@en . . "DOI: 10.1002/cjoc.201201147"@en . " "@en . . . "Drospirenone"@en . "Progestins such as drospirenone diffuse freely into target cells in the female reproductive tract, mammary gland, hypothalamus, and the pituitary and bind to the progesterone receptor. Once bound to the receptor, progestins slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH surge."@en . . "For the prevention of pregnancy in women who elect an oral contraceptive."@en . . . . . . . . . . . "95-97%"@en . . "Drospirenonum"@en . . . "DRSP"@en . . . . . . "Drospirenone is a synthetic progestin that is an analog to spironolactone. It is found in a number of birth control formulations. Drospirenone differs from other synthetic progestins in that its pharmacological profile in preclinical studies shows it to be closer to the natural progesterone. As such it has anti-mineralocorticoid properties, counteracts the estrogen-stimulated activity of the renin-angiotensin-aldosterone system, and is not androgenic. It was shown in animal studies that drospirenone exhibits antiandrogenic activity judging from accessory sex gland growth in castrated, androgen-treated, juvenile rats. "@en . . "67392-87-4"@en . . . . . "approved"@en . . . . "Oral bioavailability is approximately 76%."@en . . . . . . . . . "1,2-Dihydrospirorenone"@en . . . . . "6\u03B2,7\u03B2,15\u03B2,16\u03B2-dimethylene-3-oxo-17\u03B1-pregn-4-ene-21,17 carbolactone"@en . .