. "Synterin"@en . . "Rolitetracyclinum"@en . . . . " "@en . "751-97-3"@en . . "Pyrrolidino-methyl-tetracycline"@en . "Rolitetraciclina"@en . "Rolitetracycline is a semisynthetic broad-spectrum tetracycline antibiotic used especially for parenteral administration in cases requiring high concentrations or when oral administration is impractical. Rolitetracycline passively diffuses through porin channels in the bacterial membrane and reversibly binds to the 30S ribosomal subunit, preventing binding of tRNA to the mRNA-ribosome complex, and thus interfering with protein synthesis."@en . . "N-(1-Pyrrolidinylmethyl)-tetracycline"@en . . "Rolitetracycline"@en . "N-(Pyrrolidinomethyl)tetracycline"@en . . . . . "Rolitetracycline is a broad-spectrum antibiotic used in cases needing high concentrations or when oral administration is impractical."@en . . . . . . . . "Reverin"@en . . . . . . . . . . . . . . . . . "approved"@en . "Horacio Alfredo Priestap, Carlos Rappaport, \"Process for producing rolitetracycline.\" U.S. Patent US3985768, issued September, 1963."@en . "A pyrrolidinylmethyl tetracycline. [PubChem]"@en . "Symptoms of overdose include anorexia, nausea, diarrhoea, glossitis, dysphagia, enterocolitis and inflammatory lesions (with monilial overgrowth) in the anogenital region, skin reactions such as maculopapular and erythematous rashes, exfoliative dermatitis, photosensitivity, hypersensitivity reactions such as urticaria, angioneurotic oedema, anaphylaxis, anaphyl-actoid purpura, pericarditis, and exacerbation of systemic lupus erythematosus, benign intracranial hypertension in adults disappearing on discontinuation of the medicine, haematologic abnormalities such as haemolytic anaemia, thrombocytopenia, neutropenia, and eosinophilia. LD₅₀=262 mg/kg (I.P. in rat)."@en . . . .