"Well absorbed from gastrointestinal tract (within 1-2 hours)."@en . "Oral, mouse: LD₅₀ = 3162 mg/kg. Symptoms of overdose include abdominal cramps, diarrhea, joint and muscle pain, nausea, and vomiting."@en . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "1.5 hours"@en . . . . . . "Humans and other mammals"@en . "2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure"@en . . . . . . . . . . . . . . . . . . . . "Take 30 minutes before meals."@en . . . . . . . "For treatment of adult patients with very high elevations of serum triglyceride levels (types IV and V hyperlipidemia) who are at risk of developing pancreatitis (inflammation of the pancreas) and who do not respond adequately to a strict diet."@en . . . . "Gemfibrozil"@en . . . . . . . . . . . . . . . . . . . . . "Gemfibrozil increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. It does so by activating Peroxisome proliferator-activated receptor-alpha (PPAR\u03B1) 'transcription factor ligand', a receptor that is involved in metabolism of carbohydrates and fats, as well as adipose tissue differentiation. This increase in the synthesis of lipoprotein lipase thereby increases the clearance of triglycerides. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL. This is accompanied by a slight increase in secretion of lipids into the bile and ultimately the intestine. Gemfibrozil also inhibits the synthesis and increases the clearance of apolipoprotein B, a carrier molecule for VLDL."@en . . "approved"@en . "Lopid"@en . " "@en . . "2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid"@en . "Approximately seventy percent of the administered human dose is excreted in the urine, mostly as the glucuronide conjugate, with less than 2% excreted as unchanged gemfibrozil."@en . "25812-30-0"@en . "2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure"@en . "Gemfibrozilo"@en . "A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol. These decreases occur primarily in the VLDL fraction and less frequently in the LDL fraction. Gemfibrozil increases HDL subfractions HDL2 and HDL3 as well as apolipoproteins A-I and A-II. Its mechanism of action has not been definitely established. [PubChem]"@en . "95%"@en . . . . . . . . . . . . . "Gemfibrozil"@en . "Gianfranco Piccoli, Antonio Tarquini, Giovanni Frare, \"Process for the preparation of gemfibrozil.\" U.S. Patent US5654476, issued May, 1980."@en . . . . . . . . . . . . . . "Gemfibrozilum"@en . . . . . .