. "Approximately 94 minutes, however the metabolites have a serum half-life of 16 to 48 hours."@en . "50%"@en . . . "CeeNU"@en . . "1-(2-Chloroethyl)-3-cyclohexylnitrosourea"@en . . "CCNU"@en . . . . . . . "For the treatment of primary and metastatic brain tumors as a component of combination chemotherapy in addition to appropriate surgical and/or radiotherapeutic procedures. Also used in combination with other agents as secondary therapy for the treatment of refractory or relapsed Hodgkin's disease."@en . . . . . "Lomustine is a highly lipophilic nitrosourea compound which undergoes hydrolysis in vivo to form reactive metabolites. These metabolites cause alkylation and cross-linking of DNA (at the O6 position of guanine-containing bases) and RNA, thus inducing cytotoxicity. Other biologic effects include inhibition of DNA synthesis and some cell cycle phase specificity. Nitrosureas generally lack cross-resistance with other alkylating agents. As lomustine is a nitrosurea, it may also inhibit several key processes such as carbamoylation and modification of cellular proteins."@en . . . . "Cecenu"@en . . . . "Humans and other mammals"@en . . . . . . "N-(2-Chloroethyl)-n'-cyclohexyl-N-nitrosourea"@en . . . . . "Following oral administration of radioactive CeeNU at doses ranging from 30 mg/m2 to 100 mg/m2, about half of the radioactivity given was excreted in the urine in the form of degradation products within 24 hours."@en . . . . . . . . . . "CINU"@en . . . . . "Lomustinum"@en . . . "Lomustina"@en . "13010-47-4"@en . . "approved"@en . . "Oral, rat: LD₅₀ = 70 mg/kg. Pulmonary toxicity has been reported at cumulative doses usually greater than 1,100 mg/m2. There is one report of pulmonary toxicity at a cumulative dose of only 600 mg. The onset of toxicity has varied from 6 months after initiation of therapy, to as late as 15 years after."@en . "1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea"@en . . . . . . "Well and rapidly absorbed from the gastrointestinal tract."@en . "Belustine"@en . "An alkylating agent of value against both hematologic malignancies and solid tumors. [PubChem]"@en . . "Cyclohexyl chloroethyl nitrosourea"@en . . "Lomustine"@en . "Chloroethylcyclohexylnitrosourea"@en . . . " "@en . . . .