. . "Used in the treatment of oedema (including that associated with heart failure) and hypertension."@en . . . . . . . . . . . . . . . . . . "A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830)"@en . . . . . . . . . "Naqua"@en . . . . . . . . . . . . . "approved"@en . . "Oral Rat LD₅₀ = 5600 mg/kg, oral Mouse LD₅₀ = 2600 mg/kg"@en . "Humans and other mammals"@en . . . . . . . . . . . " "@en . . . . "133-67-5"@en . . . . "Trichlormethiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle, altering electrolyte transfer in the proximal tubule. This results in excretion of sodium, chloride, and water and, hence, diuresis. As a diuretic, Trichloromethiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like Trichloromethiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of Trichloromethiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle."@en . "Trichlormethiazide"@en . . .