. . "21256-18-8"@en . . . . "Daypro"@en . . . . . . . . "Duraprox"@en . . . "Oxaprozina"@en . . . . . . . . . "Walix"@en . . . "Oxaprozin"@en . . . . . "* 11 to 17 L/70 kg"@en . . . "Take with food, usually once a day after breakfast. Food decreases the rate of absorption but not the amount absorbed. Avoid alcohol."@en . "Oxaprozinum"@en . . . . . "Humans and other mammals"@en . . . . "# Zhou XP, Zhang MX, Sun W, Yang XH, Wang GS, Sui DY, Yu XF, Qu SC: Design, synthesis, and in-vivo evaluation of 4,5-diaryloxazole as novel nonsteroidal anti-inflammatory drug. Biol Pharm Bull. 2009 Dec;32(12):1986-90. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/19952416"@en . "# Heller B, Tarricone R: Oxaprozin versus diclofenac in NSAID-refractory periarthritis pain of the shoulder. Curr Med Res Opin. 2004 Aug;20(8):1279-90. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/15324531"@en . . "approved"@en . "Oxaprozine"@en . . "Deflam"@en . . . . . . . . . . . "Used to relieve the inflammation, swelling, stiffness, and joint pain associated with rheumatoid arthritis and osteoarthritis."@en . . . . . . . ">99.5% bound to albumin"@en . . . . . "Oral, mouse: LD₅₀ = 1210 mg/kg; Oral, rabbit: LD₅₀ = 172 mg/kg; Oral, rat: LD₅₀ = 4470 mg/kg"@en . . . . . "54.9 hours"@en . "Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis."@en . . . . . " "@en . "Oxaprozin is expected to be excreted in human milk based on its physical-chemical properties; however, the amount of oxaprozin excreted in breast milk has not been evaluated. Approximately 95% of oxaprozin is metabolized by the liver. Approximately 5% of the oxaprozin dose is excreted unchanged in the urine. Sixty-five percent (65%) of the dose is excreted in the urine and 35% in the feces as metabolite. Biliary excretion of unchanged oxaprozin is a minor pathway. Several oxaprozin metabolites have been identified in human urine or feces."@en . . . . . "Danoprox"@en . . . . "Oxaprozin is 95% absorbed after oral administration. Food may reduce the rate of absorption of oxaprozin, but the extent of absorption is unchanged. Antacids do not significantly affect the extent and rate of oxaprozin absorption."@en . . . . . . . . . . . . . . . . . . . "Anti-inflammatory effects of Oxaprozin are believed to be due to inhibition of cylooxygenase in platelets which leads to the blockage of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Oxaprozin is a non-selective NSAID, with a cell assay system showing lower COX-2 selectivity implying higher COX-1 selectivity. "@en . . . . . . . . . . "Dayrun"@en .