. . . "For the treatment of ventricular pre-excitation and cardiac dysrhythmias"@en . . . . "Chinidinum"@en . . . . "80-88%"@en . "CIN-QUIN"@en . . "(S)-(6-Methoxyquinolin-4-yl)((2R,5R)-5-vinylquinuclidin-2-yl)methanol"@en . . . . . "An optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular action potential, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission. [PubChem]"@en . "(+)-quinidine"@en . . "56-54-2"@en . . "Preferably take on an ampty stomach."@en . . . "Conchinin"@en . . . . . . . . "Jean Paul REMON, Chris Vervaet, \"QUININE AND QUINIDINE SALTS, METHODS FOR MAKING THEM, AND PHARMACEUTICAL FORMULATIONS COMPRISING THEM.\" U.S. Patent US20090239900, issued September 24, 2009."@en . . . . . . . . . . "Quinidina"@en . . "Humans and other mammals"@en . "approved"@en . . . "Kinidin"@en . . . . . "beta-Quinine"@en . . "Conquinine"@en . . . . . . . . "Quinidine acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers. Quinidine may also act on the slow inward calcium current (ICa), the rapid (IKr) and slow (IKs) components of the delayed potassium rectifier current, the inward potassium rectifier current (IKI), the ATP-sensitive potassium channel (IKATP) and Ito."@en . . "(8R,9S)-Quinidine"@en . "When the urine pH is less than 7, about 20% of administered quinidine appears unchanged in the urine, but this fraction drops to as little as 5% when the urine is more alkaline."@en . "* 2 to 3 L/kg * 0.5 L/kg [congestive heart failure] * 3 to 5 L/kg [cirrhosis of the liver]"@en . . . "6-Methoxy-alpha-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol"@en . "(R)-(6-Methoxyquinolin-4-yl)((3S,4R,7S)-3-vinylquinuclidin-7-yl)methanol"@en . . . . . . . . . . . . . . . . . . . . . . . . . "Quinidine"@en . . . . . . " "@en . . . . . " "@en . . "Chinidin"@en . . . . . . . . . . "\u03B2-quinine"@en . . . . . "6-8 hours"@en . . . . . . . . . . "(S)-(6-Methoxy-quinolin-4-yl)-((2R,5R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol"@en . . . . . . . . . "Pitayine"@en . . . "* 3 \u2013 5 mL/min/kg [adults]"@en . . . . "alpha-(6-Methoxy-4-quinolyl)-5-vinyl-2-quinuclidinemethanol"@en . . . "Quinidine"@en . . .