"For the treatment of Paget's disease of the bone (osteitis deformans), postmenopausal and glucocorticoid-induced osteoporosis"@en . "Ridron"@en . "Risedronate"@en . . . . . . . . . . "~24%"@en . "Acidum risedronicum"@en . . "Risedrons\u00E4ure"@en . " "@en . . . . . . . "Risedronate is excreted unchanged primarily via the kidney. Insignificant amounts (<0.1% of intravenous dose) of drug are excreted in the bile in rats."@en . . . "1.5 hours"@en . "Risedronate"@en . . . . . . . . "105462-24-6"@en . . . "Rapid absorption (~1 hr) after an oral dose, occurs throughout the upper gastrointestinal tract"@en . "* 13.8 L/kg"@en . . . . "Acide ris\u00E9droniqe"@en . . "Risedronic acid"@en . "approved"@en . . "Humans and other mammals"@en . . . "Srinivasa Rao V.N Divvela, Lenin Racha, Sivakumaran Meenakshisunderam, Ramesh Dandala, \"Process for the preparation of risedronate sodium hemi-pentahydrate.\" U.S. Patent US20070173484, issued July 26, 2007."@en . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Risedronate is a bisphosphonate used to strengthen bone, treat or prevent osteoporosis, and treat Paget's disease of bone."@en . . . . . . . . . . " "@en . "The action of risedronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Risedronate also targets farnesyl pyrophosphate (FPP) synthase. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting FPP synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass."@en . . . . . "Acido risedronico"@en . . "Side effects include abdominal pain, anxiety, back pain, belching, bladder irritation, bone disorders and pain, bronchitis, bursitis, cataracts, chest pain, colitis, constipation, depression, diarrhea, difficulty breathing, dizziness, dry eyes, eye infection, flu-like symptoms, gas, headache, high blood pressure, infection, insomnia, itching, joint disorders and pain, leg cramps, muscle pain, muscle weakness, nausea, neck pain, nerve pain, pain, pneumonia, rash, ringing in ears, sinus problems, sore throat, stomach bleeding, stuffy or runny nose, swelling, tendon problems, tumor, ulcers, urinary tract infection, vertigo, vision problems, and weakness."@en . . . "investigational"@en . "* 122 mL/min * 73 mL/min [osteopenic postmenopausal women]"@en . . . .