"About 38% of the administered temozolomide total radioactive dose is recovered over 7 days: 37.7% in urine and 0.8% in feces."@en . "# Neyns B, Tosoni A, Hwu WJ, Reardon DA: Dose-dense temozolomide regimens: antitumor activity, toxicity, and immunomodulatory effects. Cancer. 2010 Jun 15;116(12):2868-77. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/20564393 # Wick W, Platten M, Weller M: New (alternative) temozolomide regimens for the treatment of glioma. Neuro Oncol. 2009 Feb;11(1):69-79. Epub 2008 Sep 4. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/18772354 # Villano JL, Seery TE, Bressler LR: Temozolomide in malignant gliomas: current use and future targets. Cancer Chemother Pharmacol. 2009 Sep;64(4):647-55. Epub 2009 Jun 19. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/19543728 # Meije Y, Lizasoain M, Garcia-Reyne A, Martinez P, Rodriguez V, Lopez-Medrano F, Juan RS, Lalueza A, Aguado JM: Emergence of cytomegalovirus disease in patients receiving temozolomide: report of two cases and literature review. Clin Infect Dis. 2010 Jun 15;50(12):e73-6. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/20455691 # Trinh VA, Patel SP, Hwu WJ: The safety of temozolomide in the treatment of malignancies. Expert Opin Drug Saf. 2009 Jul;8(4):493-9. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/19435405 # Yung WK: Temozolomide in malignant gliomas. Semin Oncol. 2000 Jun;27(3 Suppl 6):27-34. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/10866347 # Friedman HS, Kerby T, Calvert H: Temozolomide and treatment of malignant glioma. Clin Cancer Res. 2000 Jul;6(7):2585-97. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/10914698 # Mutter N, Stupp R: Temozolomide: a milestone in neuro-oncology and beyond? Expert Rev Anticancer Ther. 2006 Aug;6(8):1187-204. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/16925485"@en . . "For the treatment of adult patients diagnosed with anaplastic astrocytoma whose disease has progressed after therapy with nitrosourea and procarbazine, as well as concomitantly with radiation therapy for treatment of newly diagnosed glioblastoma multiforme. Also used as maintenance therapy for glioblastoma multiforme."@en . "3,4-dihydro-3-Methyl-4-oxoimidazo(5,1-D)-as-tetrazine-8-carboxamide"@en . . . "T\u00E9mozolomide"@en . . . . . . . "Temozolomide is not active until it is converted at physiologic pH to MTIC. It is suggested that MTIC then alkylates DNA at the N7 position of guanine, O3 position of adenosine, and O6 position of guanosine, with the most common site being the N7 position. This methylation of guanine residues lead to single and double-strand DNA breaks and subsequent apoptotic cell death. It is suggested that the N7-methylguanine plays a critical role in the antitumor activity of the drug, as there is a correlation between the sensitivity of tumor cell lines to temozolomide and the activity of O6-alkylguanine alkyltransferase, which is the DNA repair protein that specifically removes alkyl groups at the O6 position of guanine. Cells lines that have lower levels of AGT are more sensitive to the cytotoxicity of temozolomide. It is also suggested that cytotoxic mechanism of temozolomide is related to the failure of the DNA MMR system to find a complementary base for methylated guanine. The DNA MMR system is involved in the formation of a number of proteins that remove methylated guanine. Evidence shows that when this repair process is targeted to the DNA strand opposite the O6-methylguanine, its inability to find the correct target leads to long-lived nicks in the DNA. The accumulation of these nicks lead to the inhibition of replication in the daughter cells, thereby blocking the cell cycle at the G₂-M boundary."@en . . . . . . . "NSC 362856"@en . "BRN 5547136"@en . "* 0.4 L/kg"@en . . . . "Temodar"@en . . . "Temodal"@en . . "3-Methyl-4-oxo-3,4-dihydroimidazo(5,1-D)(1,2,3,5)tetrazine-8-carboxamide"@en . "Temozolodida"@en . . . . "CCRG-81045"@en . . . . "Rapid and complete absorption in the gastrointestinal tract"@en . "Temozolomide (Temodar and Temodal) is an oral alkylating agent used for the treatment of refractory anaplastic astrocytoma -- a type of cancerous brain tumor. Temozolomide is not active until it is converted at physiologic pH to the active form, 5-(3-methyltriazen-1-yl)imidazole-4-carboxamide (MTIC). "@en . . "TMZ"@en . . . . . . . "CCRG 81045"@en . "Humans and other mammals"@en . . . "approved"@en . . . . "Approximately 1.8 hours."@en . . "3,4-dihydro-3-Methyl-4-oxoimidazo(5,1-D)-1,2,3,5-tetrazine-8-carboxamide"@en . . . . "* 5.5 L/hr/m2"@en . . . . "85622-93-1"@en . "Temozolomida"@en . . . "MB 39831"@en . . "m & b 39831"@en . . "15%"@en . . "Methazolastone"@en . "Sch 52365"@en . . . . . . "CCRIS 8996"@en . "investigational"@en . "Shen-Chun Kuo, \"Synthesis of temozolomide and analogs.\" U.S. Patent US20020133006, issued September 19, 2002."@en . "Temozolomid"@en . . . . . . . "8-Carbamoyl-3-methylimidazo(5,1-D)-1,2,3,5-tetrazin-4(3H)-one"@en . "Temozolomidum"@en . . . " "@en . . "M&B 39831"@en . . . . "Temozolomide"@en . . .