. . . "Fenoldopam"@en . . . . . . . . . . . . "For the in-hospital, short-term (up to 48 hours) management of severe hypertension when rapid, but quickly reversible, emergency reduction of blood pressure is clinically indicated, including malignant hypertension with deteriorating end-organ function."@en . . . . . "The most likely reaction of overdose would be excessive hypotension which should be treated with drug discontinuation and appropriate supportive measures."@en . "approved"@en . . . . . "Fenoldopamum"@en . . . "The elimination half-life is about 5 minutes in mild to moderate hypertensives, with little difference between the R (active) and S isomers."@en . . . "Fenoldopam"@en . . . . . "\"DrugSyn.org\":http://www.drugsyn.org/Fenoldopam.htm"@en . . . . . " "@en . . "F\u00E9noldopam"@en . . . "Fenoldopam is a rapid-acting vasodilator. It is an agonist for D₁-like dopamine receptors and binds with moderate affinity to α₂-adrenoceptors. It has no significant affinity for D₂-like receptors, α₁ and β-adrenoceptors, 5_HT1 and 5_HT2 receptors, or muscarinic receptors. Fenoldopam is a racemic mixture with the R-isomer responsible for the biological activity. The R-isomer has approximately 250-fold higher affinity for D₁-like receptors than does the S-isomer. In non-clinical studies, fenoldopam had no agonist effect on presynaptic D₂-like dopamine receptors, or α or β -adrenoceptors, nor did it affect angiotensin-converting enzyme activity. Fenoldopam may increase norepinephrine plasma concentration."@en . "67227-57-0"@en . . . . " "@en . . "A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation. [PubChem]"@en . . . . . . . . . "Humans and other mammals"@en . . . . . . . . . "Radiolabeled studies show that about 90% of infused fenoldopam is eliminated in urine, 10% in feces. Elimination is largely by conjugation, without participation of cytochrome P-450 enzymes. Only 4% of the administered dose is excreted unchanged."@en . . .