. . . . . . . . . . . "George H. Scherr, \"Preparation of gentamicin sensitized particles for agglutination tests.\" U.S. Patent US4100268, issued August, 1975."@en . . . . . . . . . "Injections lead to peak serum concentrations in 30-60 minutes. Topical gentamicin is readily absorbed from large burned, denuded, or granulating areas but not through intact skin. Absorption of gentamicin is faster and greater with the cream compared to the ointment. Gentamicin is absorbed in small quantities following topical application to the eye. Gentamicin is also absorbed in small amounts following topical application to the ear (especially if the eardrum is perforated or if tissue damage is present). Gentamicin is very poorly absorbed orally. "@en . . . . . . "For treatment of serious infections caused by susceptible strains of the following microorganisms: P. aeruginosa, Proteus species (indole-positive and indole-negative), E. coli, Klebsiella-Enterobactor-Serratia species, Citrobacter species and Staphylococcus species (coagulase-positive and coagulase-negative)."@en . . . "1403-66-3"@en . . "A complex of three different closely related aminoglycoside sulfates, Gentamicins C1, C2, and C1a, obtained from Micromonospora purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit protein synthesis (genetic translation). [PubChem]"@en . . . . . . "Francisella tularensis"@en . . "approved"@en . . . . . . . . . . . . . . . . . . . . "Gentamicin"@en . "Low (between 0 and 30%)"@en . " "@en . "Mild and reversible nephrotoxicity may be observed in 5 - 25% of patients. Gentamicin accumulates in proximal renal tubular cells and causes cell damage. Tubular cell regeneration occurs despite continued drug exposure. Toxicity usually occurs several days following initiation of therapy. May cause irreversible ototoxicity. Otoxocity appears to be correlated to cumulative lifetime exposure. Drug accumulation in the endolymph and perilymph of the inner ear causes irreversible damage to hair cells of the cochlea or summit of ampullar cristae in the vestibular complex. High frequency hearing is lost first with progression leading to loss of low frequency hearing. Further toxicity may lead to retrograde degeneration of the 8th cranial (vestibulocochlear) nerve. Vestibular toxicity may cause vertigo, nausea, vomiting, dizziness and loss of balance. Mouse, intravenous LD50: 52 mg/kg; rat, intravenous LD50: 96 mg/kg."@en . . . . . . . . . "Aminoglycosides like gentamicin \"irreversibly\" bind to specific 30S-subunit proteins and 16S rRNA. Specifically gentamicin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes."@en . . . . . . . . . . . . . . . "Yersinia pestis"@en . . . . . " "@en . . . . . . "3-3½ hours in infants one week to six months of age; this increases to 5½ hours in full-term and large premature infants less than one week old."@en . . "Proteus vulgaris"@en . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Pseudomonas aeruginosa"@en . . . . . . . . . . . . . . . . . . . . "Enteric bacteria and other eubacteria"@en . . . . . . . . . . . . . . . . "Gentamicin"@en . . "Serratia marcescens"@en . . . . . . . . . . . . . . . . . . . . . . .