"Signs of metyrosine overdosage include those central nervous system effects observed in some patients even at low dosages. At doses exceeding 2000 mg/day, some degree of sedation or feeling of fatigue may persist. Doses of 2000-4000 mg/day can result in anxiety or agitated depression, neuromuscular effects (including fine tremor of the hands, gross tremor of the trunk, tightening of the jaw with trismus), diarrhea, and decreased salivation with dry mouth. The acute toxicity of metyrosine was 442 mg/kg and 752 mg/kg in the female mouse and rat respectively."@en . . . . . . . "(-)-alpha-Methyl-L-tyrosine"@en . . . "Humans and other mammals"@en . . . "Metirosina"@en . "An inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. (Martindale, The Extra Pharmacopoeia, 30th ed)"@en . "Well absorbed from the gastrointestinal tract."@en . "alpha-Methyl-L-P-tyrosine"@en . . . . . . "alpha-Methyl-para-tyrosine"@en . "3.4 to 3.7 hours"@en . "Metirosinum"@en . "Metyrosine"@en . "Because the first step is also the rate-limiting step, blockade of tyrosine hydroxylase activity results in decreased endogenous levels of catecholamines, usually measured as decreased urinary excretion of catecholamines and their metabolites."@en . . "Metyrosine"@en . . " "@en . "(S)-alpha-Methyltyrosine"@en . . "Metyrosine inhibits tyrosine hydroxylase, which catalyzes the first transformation in catecholamine biosynthesis, i.e., the conversion of tyrosine to dihydroxyphenylalanine (DOPA). Because the first step is also the rate-limiting step, blockade of tyrosine hydroxylase activity results in decreased endogenous levels of catecholamines and their synthesis. This consequently, depletes the levels of the catecholamines dopamine, adrenaline and noradrenaline in the body,usually measured as decreased urinary excretion of catecholamines and their metabolites. One main end result of the catecholamine depletion is a decrease in blood presure."@en . . . . "Metirosin"@en . "L-alpha-Methyltyrosine"@en . "Methyltyrosine"@en . "M\u00E9tirosine"@en . . "\"DrugSyn.org\":http://www.drugsyn.org/Metyrosine.htm"@en . . . "Metirosine"@en . . . . . "alpha-Methyl-P-tyrosine"@en . "For use in the treatment of patients with pheochromocytoma, for preoperative preparation of patients for surgery, management of patients when surgery is contraindicated, and chronic treatment of patients with malignant pheochromocytoma."@en . . . . . "672-87-7"@en . . . . "approved"@en . . . . . . . . . . . . "alpha-Methyltyrosine"@en . . . . .