. . . . . "# Frieling H, Bleich S: Tranylcypromine: new perspectives on an \"old\" drug. Eur Arch Psychiatry Clin Neurosci. 2006 Aug;256(5):268-73. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/16927039 # Nolen WA: [Classical monoamine oxidase inhibitor: not registered for, but still a place in the treatment of depression] Ned Tijdschr Geneeskd. 2003 Oct 4;147(40):1940-3. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/14574774"@en . . . . . "Humans and other mammals"@en . . . . "A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311)"@en . "Tranylcypromin"@en . . "Tranylcypromine"@en . . "Tranylcypromine"@en . "155-09-9"@en . "Tranilcipromina"@en . . . "approved"@en . . . . . . "For the treatment of major depressive episode without melancholia."@en . . "Transamine"@en . " "@en . "Interindividual variability in absorption. May be biphasic in some individuals. Peak plasma concentrations occur in one hour following oral administration with a secondary peak occurring within 2-3 hours. Biphasic absorption may represent different rates of absorption of the stereoisomers of the drug, though additional studies are required to confirm this. "@en . . . "Avoid aged foods (chesse, red wine), pickled foods, cured foods (bacon/ham), chocolate, fava beans, beer, unless approved by your physician."@en . . . " "@en . . . . . . . . . . . "Tranylcyprominum"@en . . . . . . . . . . "Avoid St. John's Wort."@en . "Avoid alcohol."@en . . "Avoid excessive quantities of coffee or tea (caffeine)."@en . "In overdosage, some patients exhibit insomnia, restlessness and anxiety, progressing in severe cases to agitation, mental confusion and incoherence. Hypotension, dizziness, weakness and drowsiness may occur, progressing in severe cases to extreme dizziness and shock. A few patients have displayed hypertension with severe headache and other symptoms. Rare instances have been reported in which hypertension was accompanied by twitching or myoclonic fibrillation of skeletal muscles with hyperpyrexia, sometimes progressing to generalized rigidity and coma."@en . . "1.5-3.2 hours in patients with normal renal and hepatic function"@en . . . . "1.1-5.7 L/kg"@en . "Tranylcypromine irreversibly and nonselectively inhibits monoamine oxidase (MAO). Within neurons, MAO appears to regulate the levels of monoamines released upon synaptic firing. Since depression is associated with low levels of monoamines, the inhibition of MAO serves to ease depressive symptoms, as this results in an increase in the concentrations of these amines within the CNS."@en . "Parnate"@en . . . . . . . . . .