"For the treatment of amyotrophic lateral sclerosis (ALS, Lou Gehrig's Disease)"@en . . "investigational"@en . . . "Riluzol"@en . "Pratap Padi, Madhusudhan Ganta, Satyanarayana Bollikonda, Sridhar Chaganti, Ramulu Akula, Loka Maheshwari Dommati, \"PROCESS FOR PREPARING RILUZOLE.\" U.S. Patent US20080108827, issued May 08, 2008."@en . . "The mean elimination half-life of riluzole is 12 hours (CV=35%) after repeated doses."@en . "96% bound to plasma proteins, mainly to albumin and lipoprotein over the clinical concentration range."@en . . . . "1744-22-5"@en . . . . . . . . . . . . . "Humans and other mammals"@en . . . . . " "@en . . . . . . "A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis. Riluzole is marketed as Rilutek by Sanofi. "@en . "# Song JH, Huang CS, Nagata K, Yeh JZ, Narahashi T: Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels. J Pharmacol Exp Ther. 1997 Aug;282(2):707-14. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/9262334 # Coric V, Taskiran S, Pittenger C, Wasylink S, Mathalon DH, Valentine G, Saksa J, Wu YT, Gueorguieva R, Sanacora G, Malison RT, Krystal JH: Riluzole augmentation in treatment-resistant obsessive-compulsive disorder: an open-label trial. Biol Psychiatry. 2005 Sep 1;58(5):424-8. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/15993857 # van Kan HJ, Groeneveld GJ, Kalmijn S, Spieksma M, van den Berg LH, Guchelaar HJ: Association between CYP1A2 activity and riluzole clearance in patients with amyotrophic lateral sclerosis. Br J Clin Pharmacol. 2005 Mar;59(3):310-3. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/15752377 # Zarate CA Jr, Payne JL, Quiroz J, Sporn J, Denicoff KK, Luckenbaugh D, Charney DS, Manji HK: An open-label trial of riluzole in patients with treatment-resistant major depression. Am J Psychiatry. 2004 Jan;161(1):171-4. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/14702270 # Mathew SJ, Manji HK, Charney DS: Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/18172433 # Lamanauskas N, Nistri A: Riluzole blocks persistent Na+ and Ca2+ currents and modulates release of glutamate via presynaptic NMDA receptors on neonatal rat hypoglossal motoneurons in vitro. Eur J Neurosci. 2008 May;27(10):2501-14. Epub 2008 Apr 26. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/18445055"@en . "approved"@en . . "The mode of action of riluzole is unknown. Its pharmacological properties include the following, some of which may be related to its effect: 1) an inhibitory effect on glutamate release (activation of glutamate reuptake), 2) inactivation of voltage-dependent sodium channels, and 3) ability to interfere with intracellular events that follow transmitter binding at excitatory amino acid receptors."@en . . . . . . . . . . . . . . . . "Riluzole"@en . . . . . . . . . . "Riluzolum"@en . . "Riluzole is well-absorbed (approximately 90%), with average absolute oral bioavailability of about 60% (CV=30%). A high fat meal decreases absorption, reducing AUC by about 20% and peak blood levels by about 45%."@en . . "Riluzole"@en . . . "Take on an empty stomach 1 hour before or 2 hours after meals."@en . . .